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Eosinophils infiltrating interleukin-5 gene-transfected tumors do not suppress tumor growth
- Source :
- European journal of immunology. 23(4)
- Publication Year :
- 1993
-
Abstract
- Tumor-associated eosinophils have been observed in human tumors and in experimental tumor models, but their function is poorly understood. To study the role of eosinophils during tumor growth, the plasmacytoma J558L and the mammary adenocarcinoma TS/A were transfected with an expression vector encoding the murine gene for interleukin-5 (IL-5), a cytokine inducing proliferation and activation of eosinophils. Injection of parental cells, mock-transfectants and IL-5-producing cells into syngeneic mice showed that local IL-5 secretion induced rapid tumor infiltration by eosinophils, as evidenced by immunohistochemical staining, but nevertheless did not alter the tumor growth kinetics of IL-5 transfectants. Therefore, the mere presence of IL-5 and eosinophils was not sufficient to induce a protective host immune response.
- Subjects :
- Adoptive cell transfer
medicine.medical_treatment
Immunology
Molecular Sequence Data
Biology
medicine.disease_cause
Transfection
Polymerase Chain Reaction
Mice
Immune system
medicine
Immunology and Allergy
Animals
Interleukin 5
Immunity, Cellular
Mice, Inbred BALB C
Base Sequence
Neoplasms, Experimental
Eosinophil
medicine.disease
Eosinophils
medicine.anatomical_structure
Cytokine
Oligodeoxyribonucleotides
Cancer research
Plasmacytoma
Female
Interleukin-5
Carcinogenesis
Subjects
Details
- ISSN :
- 00142980
- Volume :
- 23
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- European journal of immunology
- Accession number :
- edsair.doi.dedup.....0db42a6b2986deb7e0b808af89db281e