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The Emerging Function of PKCtheta in Cancer
- Source :
- Biomolecules, Biomolecules, Vol 11, Iss 221, p 221 (2021)
- Publication Year :
- 2020
-
Abstract
- Protein Kinase C theta (PKCθ) is a serine/threonine kinase that belongs to the novel PKC subfamily. In normal tissue, its expression is restricted to skeletal muscle cells, platelets and T lymphocytes in which PKCθ controls several essential cellular processes such as survival, proliferation and differentiation. Particularly, PKCθ has been extensively studied for its role in the immune system where its translocation to the immunological synapse plays a critical role in T cell activation. Beyond its physiological role in immune responses, increasing evidence implicates PKCθ in the pathology of various diseases, especially autoimmune disorders and cancers. In this review, we discuss the implication of PKCθ in various types of cancers and the PKCθ-mediated signaling events controlling cancer initiation and progression. In these types of cancers, the high PKCθ expression leads to aberrant cell proliferation, migration and invasion resulting in malignant phenotype. The recent development and application of PKCθ inhibitors in the context of autoimmune diseases could benefit the emergence of treatment for cancers in which PKCθ has been implicated.
- Subjects :
- 0301 basic medicine
T cell
lcsh:QR1-502
Context (language use)
Review
Biology
Biochemistry
lcsh:Microbiology
Immunological synapse
Autoimmune Diseases
03 medical and health sciences
0302 clinical medicine
Immune system
Th2 Cells
Cell Movement
Neoplasms
PKCtheta
medicine
Animals
Humans
cancer
Neoplasm Invasiveness
Protein Interaction Domains and Motifs
Neoplasm Metastasis
Molecular Biology
Protein kinase C
Cell Proliferation
Kinase
NF-kappa B
Skeletal muscle
Cancer
medicine.disease
Gene Expression Regulation, Neoplastic
mechanisms of action
Protein Subunits
030104 developmental biology
medicine.anatomical_structure
Protein Kinase C-theta
030220 oncology & carcinogenesis
tumoral function
Cancer research
Th17 Cells
Protein Binding
Signal Transduction
Subjects
Details
- ISSN :
- 2218273X
- Volume :
- 11
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Biomolecules
- Accession number :
- edsair.doi.dedup.....0db11426d910acb10863314390bdf8c7