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Blood viscosity and aging
- Publication Year :
- 2000
-
Abstract
- The objective of this study was to evaluate the relationship of whole blood viscosity and its major determinants (plasma fibrinogen level, hematocrit, hemoglobin and blood cell count) to advancing age. A total of 249 subjects (mean age 49.9+/-21.5; range 19-102 years) were included in the study. They were divided into three groups, (A)30 years of age, n, 58; (B) 30-60 years, n, 107; (C)60 years, n, 84. Whole blood viscosity at two different rates of shear (450 and 45 s(-1)) was evaluated using a cone-plate digital viscosimeter. The hematological parameters (hematocrit, hemoglobin and blood cell count) were evaluated using an automatic Coulter Counter. Plasma fibrinogen concentration was measured by a clotting method. When both sexes are considered together, whole blood viscosity shows no significant difference among age groups. Plasma fibrinogen concentration significantly increases with age (P0.001); hemoglobin, red blood cell count and platelet count, on contrary, are significantly lower in aged group. In the male sex, blood viscosity at higher shear rate (450 s(-1)) negatively correlates with advancing age (P0.005). The age-related decrease of hematocrit value in the male sex accounts for this occurrence.
- Subjects :
- Aging
medicine.medical_specialty
Health (social science)
medicine.diagnostic_test
business.industry
Blood viscosity
Viscometer
Hematocrit
Fibrinogen
Blood cell
medicine.anatomical_structure
Endocrinology
Internal medicine
Immunology
medicine
Platelet
Hemorheology
Hemoglobin
Geriatrics and Gerontology
business
Gerontology
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....0dae5f6c4a9b3acf4c41c41c72ceb1bd