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Neurotoxicity of Human Immunodeficiency Virus-1: Viral Proteins and Axonal Transport
- Source :
- Neurotoxicity Research. 21:79-89
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Human immunodeficiency virus-1 (HIV) infection of the central nervous system may cause a neurological syndrome termed HIV-associated neurocognitive disorder (HAND) which includes minor neurocognitive disorders or a more severe form of motor and cognitive impairments. Although treatment with highly active antiretroviral agents decreases the load of HIV in the brain, the prevalence of mild forms of HAND is actually increased due to longer life. Therefore, adjunctive and combined therapies must be developed to prevent and perhaps reverse the neurologic deficits observed in individuals with HAND. Key to developing effective therapies is a better understanding of the molecular and cellular mechanisms by which the virus causes this disorder. A number of HIV proteins has been shown to be released from HIV-infected cells. Moreover, these proteins have been shown to possess neurotoxic properties. This review describes new evidence of a direct interaction of the HIV protein gp120 with neurons, which might play a role in the etiopathology of HAND.
- Subjects :
- medicine.medical_specialty
Neurology
Human Immunodeficiency Virus Proteins
Central nervous system
Apoptosis
HIV Envelope Protein gp120
Biology
Toxicology
Axonal Transport
Microtubules
Article
Virus
Chemokine receptor
medicine
Humans
Neurochemistry
Nerve Growth Factors
Neurons
General Neuroscience
Neurotoxicity
Brain
medicine.disease
Axons
Protein Transport
medicine.anatomical_structure
Gene Products, tat
Immunology
HIV-1
Axoplasmic transport
Neurocognitive
Subjects
Details
- ISSN :
- 14763524 and 10298428
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Neurotoxicity Research
- Accession number :
- edsair.doi.dedup.....0dae4301db8b81ff71fe4565b9f86eb5
- Full Text :
- https://doi.org/10.1007/s12640-011-9279-2