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A New Retinal Detachment Treatment Model for Evaluation of Vitreous Tamponades
- Source :
- Current Eye Research. 46:373-379
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Purpose: To develop a treatment model of rhegmatogenous retinal detachment (RRD) in which the effects of various vitreous tamponades can be explored. Methods: In a primary session, detachment was produced in the right eye of 24 rabbits using vitrectomy, posterior vitreous detachment, retinal break induction, and subretinal injection of viscoelastic solution. The following day, detachments were treated in 16 eyes using SF6 (n = 8) or Healaflow® (HF, a cross-linked hyaluronic acid hydrogel, n = 8) tamponade. Animals were followed for 1 month and thereafter examined macroscopically and morphologically in hematoxylin and eosin-stained sections. Results: Retinal detachment (RD) was successfully treated using repeated surgery. Two HF eyes developed progressive vitritis and were excluded from further evaluation. Enlargement of the initial retinal rupture with concomitant RD was seen in 4/8 SF6 eyes, while all 6 HF eyes displayed an attached retina. Attached areas showed a normal retinal morphology except for in 1 HF eye with extensive degeneration. Conclusions: The RRD repeat vitrectomy model offers a possibility to explore the efficacy and complications of novel potential vitreous tamponades. Gel-based Healaflow® displays excellent anatomic reattachment, however, vitritis and retinal degeneration in some cases warrants further investigation.
- Subjects :
- Retinal degeneration
medicine.medical_specialty
genetic structures
medicine.medical_treatment
H&E stain
Vitrectomy
Endotamponade
Posterior vitreous detachment
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Ophthalmology
medicine
Animals
Retina
business.industry
Retinal Detachment
Retinal detachment
Retinal
medicine.disease
eye diseases
Sensory Systems
Vitreous Body
Disease Models, Animal
medicine.anatomical_structure
chemistry
030221 ophthalmology & optometry
Rabbits
sense organs
Tamponade
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14602202 and 02713683
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Current Eye Research
- Accession number :
- edsair.doi.dedup.....0d9e2eedaa13673e51b163e818836565