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Differential Effect of White-Matter Lesions and Covert Brain Infarcts on the Risk of Ischemic Stroke and Intracerebral Hemorrhage: Table
- Source :
- Stroke, Stroke, American Heart Association, 2016, 47 (7), pp.1923-1925. ⟨10.1161/STROKEAHA.116.012734⟩
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- Background and Purpose— We examined the association of white-matter hyperintensity (WMH) volume and covert brain infarcts, which are the 2 major magnetic resonance imaging markers of covert cerebrovascular disease in older adults, with long-term risk of ischemic stroke and intracerebral hemorrhage (ICH) in the general population. Methods— Participants were 1731 individuals aged ≥65 years from the Three-City Dijon study. We studied the association of WMH volume and brain infarct, with incident ischemic stroke overall, and by subtype, and with incident ICH. Results— High total, periventricular, and deep WMHs were associated with incident ICH. Extensive periventricular WMH volume was associated with increased risk of ischemic stroke (hazard ratio, 1.94; 95% confidence interval, 1.12–3.35), particularly cardioembolic stroke. Covert brain infarcts were associated with incident ICH but not with incident ischemic stroke or its subtypes. Conclusions— Although of ischemic nature, both WMH volume and covert brain infarcts portend a major risk of ICH. If confirmed in independent studies, these findings could have important implications for the clinical management of covert vascular brain lesions.
- Subjects :
- Male
Risk
medicine.medical_specialty
brain
Population
behavioral disciplines and activities
Brain Ischemia
infarctioncerebral hemorrhage
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
030212 general & internal medicine
cardiovascular diseases
education
Stroke
Aged
Cerebral Hemorrhage
Aged, 80 and over
Advanced and Specialized Nursing
Intracerebral hemorrhage
education.field_of_study
medicine.diagnostic_test
business.industry
Incidence
[SCCO.NEUR]Cognitive science/Neuroscience
Hazard ratio
Magnetic resonance imaging
Cerebral Infarction
medicine.disease
Magnetic Resonance Imaging
White Matter
stroke
Hyperintensity
nervous system diseases
cerebral small-vessel diseases
Covert
Anesthesia
Ischemic stroke
Cardiology
Female
France
Neurology (clinical)
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 00392499 and 15244628
- Database :
- OpenAIRE
- Journal :
- Stroke, Stroke, American Heart Association, 2016, 47 (7), pp.1923-1925. ⟨10.1161/STROKEAHA.116.012734⟩
- Accession number :
- edsair.doi.dedup.....0d8af64628d53107f243c0167363feda