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An update on intracerebral stem cell grafts
- Source :
- Expert review of neurotherapeutics. 18(7)
- Publication Year :
- 2018
-
Abstract
- Introduction: Primary neurological disorders are notoriously debilitating and deadly, and over the past four decades stem cell therapy has emerged as a promising treatment. Translation of stem cell therapies from the bench to the clinic requires a better understanding of delivery protocols, safety profile, and efficacy in each disease. Areas covered: In this review, benefits and risks of intracerebral stem cell transplantation are presented for consideration. Milestone discoveries in stem cell applications are reviewed to examine the efficacy and safety of intracerebral stem cell transplant therapy for disorders of the central nervous system and inform design of translatable protocols for clinically feasible stem cell-based treatments. Expert commentary: Intracerebral administration, compared to peripheral delivery, is more invasive and carries the risk of open brain surgery. However, direct cell implantation bypasses the blood–brain barrier and reduces the first-pass effect, effectively increasing the therapeutic cell deposition at its intended site of action. These benefits must be weighed with the risk of graft-versus-host immune response. Rigorous clinical trials are underway to assess the safety and efficacy of intracerebral transplants, and if successful will lead to widely available stem cell therapies for neurologic diseases in the coming years.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Parkinson's disease
Traumatic brain injury
medicine.medical_treatment
multi-system atrophy
Neuroprotection
03 medical and health sciences
Graft vs Host Reaction
0302 clinical medicine
Huntington's disease
Central Nervous System Diseases
Risk Factors
Internal medicine
Medicine
Animals
Humans
Pharmacology (medical)
amyotrophic lateral sclerosi
Amyotrophic lateral sclerosis
Stem cell
business.industry
General Neuroscience
Multiple sclerosis
traumatic brain injury
Stem-cell therapy
medicine.disease
stroke
030104 developmental biology
Blood-Brain Barrier
multiple sclerosi
Parkinson’s disease
neuroprotection
Neurology (clinical)
business
030217 neurology & neurosurgery
Huntington’s disease
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 17448360
- Volume :
- 18
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Expert review of neurotherapeutics
- Accession number :
- edsair.doi.dedup.....0d8a0edf70e2a71d34ee6a79e19dd0ea