Chicken as Reservoir for Extraintestinal Pathogenic Escherichia coli in Humans, Canada

Urinary tract infections can be difficult and expensive to treat. Most (85%) are caused by bacteria called E. coli. Historically, doctors have believed that these urinary tract E. coli came from the patient’s own intestines. But recently, Canadian researchers discovered that not only can these E. coli come from outside the patient’s intestines, they can actually come from outside the patient: from food. After comparing the genetic makeup of E. coli from human urinary tract infections with E. coli from retail meat (chicken, beef, and pork), they concluded that chickens are a likely source of E. coli and that the infections probably come directly from the chickens themselves, not from human contamination during food processing. Therefore, prevention of E. coli urinary tract infections in people might need to start on chicken farms.
We previously described how retail meat, particularly chicken, might be a reservoir for extraintestinal pathogenic Escherichia coli (ExPEC) causing urinary tract infections (UTIs) in humans. To rule out retail beef and pork as potential reservoirs, we tested 320 additional E. coli isolates from these meats. Isolates from beef and pork were significantly less likely than those from chicken to be genetically related to isolates from humans with UTIs. We then tested whether the reservoir for ExPEC in humans could be food animals themselves by comparing geographically and temporally matched E. coli isolates from 475 humans with UTIs and from cecal contents of 349 slaughtered animals. We found genetic similarities between E. coli from animals in abattoirs, principally chickens, and ExPEC causing UTIs in humans. ExPEC transmission from food animals could be responsible for human infections, and chickens are the most probable reservoir.