Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers

International audience; A series of secondary amine-substituted isoindoline-1,3-dione-4-aminoquinolines were prepared viamicrowave heating and assayed for their anti-mycobacterial activities. The compound with a butyl chainas a spacer between the two pharmacophores and piperidine as the secondary amine component onthe isoindoline ring was the most potent and non-cytotoxic among the synthesized compounds,exhibiting a minimum inhibitory concentration (MIC99) of 6.25 mg mL1 against Mycobacteriumtuberculosis.