Back to Search
Start Over
Effects of chronic luteinizing hormone-releasing hormone agonist treatment on dysfunctional uterine bleeding in the stumptailed macaque
- Source :
- Acta Endocrinologica. 106:381-386
- Publication Year :
- 1984
- Publisher :
- Oxford University Press (OUP), 1984.
-
Abstract
- Dysfunctional uterine bleeding is a disorder which presents problems for effective treatment and management. We have utilized the ability of chronic LRH agonist treatment to suppress ovarian steroid production to examine its effects on stumptailed macaques with a detailed history of excessive days of menstrual bleeding. Five monkeys were treated for 6 months with daily injections of D-Ser[But]6 LRH (1–9) nonapeptideethylamide. This was successful in suppressing ovarian steroid production in all monkeys as indicated by the maintenance of serum concentrations of oestradiol at < 100 pg/ml and progesterone at < 1 ng/ml. All monkeys menstruated for their typical time period during the first treatment cycle, but thereafter bleeding stopped in 2 monkeys and was considerably reduced in a further 2. In the remaining monkey, no significant improvement occurred. The results indicate that suppression of ovarian function in this way may have a significant role to play in the treatment of dysfunctional uterine bleeding.
- Subjects :
- Agonist
medicine.medical_specialty
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Dysfunctional uterine bleeding
Luteinizing hormone-releasing hormone agonist
Buserelin
Macaque
Endocrinology
Ovarian function
biology.animal
Internal medicine
medicine
Animals
Effective treatment
Ovarian steroid
Progesterone
Dose-Response Relationship, Drug
Estradiol
biology
business.industry
Ovary
Uterus
General Medicine
Menstruation
Menstrual bleeding
Macaca
Female
Uterine Hemorrhage
medicine.symptom
business
Subjects
Details
- ISSN :
- 1479683X and 08044643
- Volume :
- 106
- Database :
- OpenAIRE
- Journal :
- Acta Endocrinologica
- Accession number :
- edsair.doi.dedup.....0d820ae154be2d8bff8ec174c83a75e2