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A Trial of Sertraline or Cognitive Behavior Therapy for Depression in Epilepsy
- Source :
- Annals of Neurology. 86:552-560
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- OBJECTIVE Limited evidence is available to guide treatment of depression for persons with epilepsy. We evaluated the comparative effectiveness of sertraline and cognitive behavior therapy (CBT) for depression, quality of life, seizures, and adverse treatment effects. METHODS We randomly assigned 140 adult outpatients with epilepsy and current major depressive disorder to sertraline or weekly CBT for 16 weeks. The primary outcome was remission from depression based on the Mini International Neuropsychiatric Interview (MINI). Secondary outcomes included the Quality of Life in Epilepsy Inventory-89 (QOLIE-89) seizure rates, the Adverse Events Profile (AEP), the Beck Depression Inventory, and MINI Suicide Risk Module. RESULTS In the intention-to-treat analysis, 38 (52.8%; 95% confidence interval [CI] = ±12) of the 72 subjects assigned to sertraline and 41 (60.3%; 95% CI = ±11.6) of the 68 subjects in the CBT group achieved remission; the lower bound of efficacy for both groups was greater than our historical placebo control group upper bound of 33.7%. Difference in time to remission between groups was 2.8 days (95% CI = ±0.43; p = 0.79). The percent improvement of mean QOLIE-89 scores was significant for both the CBT (25.7%; p
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
Placebo
Article
Young Adult
03 medical and health sciences
Epilepsy
0302 clinical medicine
Sertraline
Internal medicine
Humans
Medicine
Depression (differential diagnoses)
Aged
Mini-international neuropsychiatric interview
Depressive Disorder, Major
Cognitive Behavioral Therapy
business.industry
Beck Depression Inventory
Middle Aged
medicine.disease
Cognitive behavioral therapy
Treatment Outcome
030104 developmental biology
Neurology
Major depressive disorder
Female
Neurology (clinical)
business
Selective Serotonin Reuptake Inhibitors
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 15318249 and 03645134
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Annals of Neurology
- Accession number :
- edsair.doi.dedup.....0d7f61c0e3c613f01942c8427c854fd3