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Outcome of Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia Patients with Central Nervous System Involvement
- Source :
- Biology of Blood and Marrow Transplantation. 20(12):2029-2033
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Central nervous system (CNS) involvement in adult acute myeloid leukemia (AML) is rare and associated with poor outcomes. Therefore, CNS involvement in AML is an indicator for allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the impact of CNS involvement in AML on the outcome of allo-HSCT remains unclear. We performed a large-scale nationwide retrospective analysis to elucidate the outcomes of allo-HSCT on AML with CNS involvement (CNS+AML). Clinical data were collected from a registry database of the Japan Society for Hematopoietic Cell Transplantation. CNS involvement was defined as the infiltration of leukemia cells into the CNS or myeloid sarcoma in the CNS identified at any time from diagnosis to transplantation. One hundred fifty-seven patients with CNS+AML underwent allo-HSCT between 2006 and 2011. The estimated overall survival, cumulative incidence of relapse and nonrelapse mortality at 2 years for CNS+AML (51.2%, 30.2%, and 14.5%, respectively) were comparable with those for AML without CNS involvement (48.6%, 27.4%, and 22.0%, respectively). Univariate and multivariate analyses indicated that the development of chronic graft-versus-host disease, disease status, and cytogenetic risk category were independent prognostic factors for overall survival for CNS+AML. These results suggest that allo-HSCT may improve outcomes in patients with CNS+AML.
- Subjects :
- Adult
Male
Adolescent
medicine.medical_treatment
Graft vs Host Disease
Disease
Hematopoietic stem cell transplantation
Disease-Free Survival
Central Nervous System Neoplasms
Japan
Recurrence
hemic and lymphatic diseases
Myeloid sarcoma
Medicine
Humans
Cumulative incidence
Sarcoma, Myeloid
neoplasms
Aged
Retrospective Studies
Aged, 80 and over
Transplantation
Acute myeloid leukemia
business.industry
Hematopoietic Stem Cell Transplantation
Myeloid leukemia
Adult Acute Myeloid Leukemia
Hematology
Middle Aged
medicine.disease
Allografts
Central nervous system involvement
Survival Rate
Leukemia
Leukemia, Myeloid, Acute
surgical procedures, operative
Immunology
Chronic Disease
Female
business
Subjects
Details
- ISSN :
- 10838791
- Volume :
- 20
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Biology of Blood and Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....0d7764b3c5248d0c48512735816d09b0
- Full Text :
- https://doi.org/10.1016/j.bbmt.2014.09.001