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Identification of aberrantly expressed miRNAs in rectal cancer
- Source :
- Oncology reports. 28(1)
- Publication Year :
- 2011
-
Abstract
- Disturbance of miRNA expression may play a key role in the initiation and progression of colorectal cancer (CRC). CRC should be viewed as a heterogeneous disease, but previous studies have only screened dysregulated miRNAs in CRC from a panel of 96, 145, 287 and 455 miRNAs, respectively. It is necessary to identify new aberrantly expressed miRNAs in rectal cancer. In this study tissue samples were derived from patients undergoing a surgical procedure to remove a portion of cancers. The expression profile of 904 miRNAs was analyzed using a miRCURY™ LNA Array from 6-paired rectal cancers and normal tissues. The expression levels of 4 miRNAs were compared by real-time PCR between colon and rectal cancer, and also the expression levels of metastatic miRNAs in different stages of rectal cancer were analyzed. We found that 67 miRNA precursors are upregulated in rectal cancer (p
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Transcription, Genetic
Colorectal cancer
Disease
Biology
Real-Time Polymerase Chain Reaction
Internal medicine
microRNA
medicine
Cluster Analysis
Humans
Oligonucleotide Array Sequence Analysis
Regulation of gene expression
Oncogene
Rectal Neoplasms
Gene Expression Profiling
General Medicine
medicine.disease
Molecular medicine
Gene expression profiling
Gene Expression Regulation, Neoplastic
MicroRNAs
Real-time polymerase chain reaction
Colonic Neoplasms
Subjects
Details
- ISSN :
- 17912431
- Volume :
- 28
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Oncology reports
- Accession number :
- edsair.doi.dedup.....0d74f976e37adfea8771265c01861c2d