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Dental caries and enamelin haplotype

Authors :
S. Opsahl Vital
Hervé Tassery
J.-Y. Sire
T. Davit-Béal
Frédéric Courson
A.G. Laffont
Catherine Chaussain
O. Chabadel
O. Laboux
C. Beldjord
E. Moulis
D. Droz
Alexandre Alcaïs
Barbara Gasse
J.M. Treluyer
J.C. Carel
Martine Hennequin
F. Vaysse
N. Bouazza
Evolution et développement du squelette (EDS)
Evolution Paris-Seine
Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (1965 - 2019) (UNS)
COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Sorbonne Paris Cité (USPC)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (1965 - 2019) (UNS)
COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Sorbonne Paris Cité (USPC)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)
AP-HP, France [CRC 06063 CARIOGENE]
Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Université Nice Sophia Antipolis (... - 2019) (UNS)
COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université des Antilles (UA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Sorbonne Paris Cité (USPC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Université Nice Sophia Antipolis (... - 2019) (UNS)
COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université des Antilles (UA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Sorbonne Paris Cité (USPC)
Source :
Journal of Dental Research, Journal of Dental Research, 2014, 93 (4), pp.360-365. ⟨10.1177/0022034514522060⟩, Journal of Dental Research, SAGE Publications (UK and US), 2014, 93 (4), pp.360-365. ⟨10.1177/0022034514522060⟩
Publication Year :
2014

Abstract

International audience; In the literature, the enamelin gene ENAM has been repeatedly designated as a possible candidate for caries susceptibility. Here, we checked whether ENAM variants could increase caries susceptibility. To this aim, we sequenced coding exons and exon-intron boundaries of ENAM in 250 children with a severe caries phenotype and in 149 caries-free patients from 9 French hospital groups. In total, 23 single-nucleotide polymorphisms (SNPs) were found, but none appeared to be responsible for a direct change of ENAM function. Six SNPs had a high minor allele frequency (MAF) and 6 others were identified for the first time. Statistical and evolutionary analyses showed that none of these SNPs was associated with caries susceptibility or caries protection when studied separately and challenged with environmental factors. However, haplotype interaction analysis showed that the presence, in a same variant, of 2 exonic SNPs (rs7671281 and rs3796704; MAF 0.12 and 0.10, respectively), both changing an amino acid in the protein region encoded by exon 10 (p.I648T and p.R763Q, respectively), increased caries susceptibility 2.66-fold independent of the environmental risk factors. These findings support ENAM as a gene candidate for caries susceptibility in the studied population.

Details

ISSN :
15440591 and 00220345
Volume :
93
Issue :
4
Database :
OpenAIRE
Journal :
Journal of dental research
Accession number :
edsair.doi.dedup.....0d6e4293e455dd4d6a2eecb318d23797
Full Text :
https://doi.org/10.1177/0022034514522060⟩