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Effect of statin therapy on mortality in patients with infective endocarditis
- Source :
- The American journal of cardiology. 114(1)
- Publication Year :
- 2014
-
Abstract
- The aim of our study was to determine whether pre-emptive statin therapy was associated with improved outcome of infective endocarditis (IE). We conducted a nationwide, population-based, propensity score-matched cohort study with the Taiwan's National Health Insurance Research Database. All patients with IE between January 2000 and December 2010 were enrolled. The primary outcome was in-hospital mortality. The secondary outcome included all-cause mortality within the first 3 months, 6 months, and one year after the diagnosis of IE. Among 13,584 patients with IE, we applied propensity score-matching on a 1:4 ratio, in which 370 statin users were matched to 1,480 statin non-users. Compared with statin non-users, statin users had a significantly lower risk of in-hospital mortality (adjusted hazard ratio [aHR] 0.65, 95% confidence interval [CI], 0.49–0.86). The reduction in mortality from IE remained significant for follow-up 3 months (aHR 0.68, 95% CI, 0.53–0.88), 6 months (aHR 0.73, 95% CI, 0.58–0.91), and 12 months (aHR 0.68, 95% CI, 0.55–0.84). Statin therapy was associated with a reduced risk of ICU admission rates, shock events, the need for mechanical ventilation, but not significantly with the need for heart valvular replacement surgery. In conclusion, our study found that statin therapy is associated with a reduced risk of in-hospital and subsequent mortality of IE.
- Subjects :
- Male
medicine.medical_specialty
Statin
medicine.drug_class
Taiwan
Comorbidity
Lower risk
Internal medicine
Cause of Death
medicine
Endocarditis
Humans
Hospital Mortality
Propensity Score
Cause of death
Aged
Retrospective Studies
business.industry
Hazard ratio
Retrospective cohort study
Middle Aged
medicine.disease
Surgery
Infective endocarditis
Cardiology
Female
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiology and Cardiovascular Medicine
business
Cohort study
Subjects
Details
- ISSN :
- 18791913
- Volume :
- 114
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The American journal of cardiology
- Accession number :
- edsair.doi.dedup.....0d68ee728664ebd8d71cdd47f7da184c