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Reproductive technologies, female infertility, and the risk of imprinting-related disorders
- Source :
- Clinical Epigenetics
- Publication Year :
- 2020
-
Abstract
- Background Epidemiological studies suggest that singletons born from assisted reproductive technologies (ART) have a high risk of adverse perinatal outcomes, specifically for imprinting disorders. Because ART processes take place at times when epigenetic reprogramming/imprinting are occurring, there is concern that ART can affect genomic imprints. However, little is currently known about the risk of imprinting defects according to the type of ART or the type of underlying female infertility. From the French national health database, a cohort of 3,501,495 singletons born over a 5-year period (2013–2017) following fresh embryo or frozen embryo transfers (fresh-ET or FET from in vitro fertilization), intrauterine insemination, or natural conception was followed up to early childhood. Based on clinical features, several syndromes/diseases involving imprinted genes were monitored. The effects of ART conception and the underlying cause of female infertility were assessed. Results Compared with infants conceived naturally, children born after fresh-ET had a higher prevalence of imprinting-related diseases, with an aOR of 1.43 [95% CI 1.13–1.81, p = 0.003]. Namely, we observed an increased risk of neonatal diabetes mellitus (1.96 aOR [95% CI 1.43–2.70], p p = 0.02). Young and advanced maternal age, primiparity, obesity, smoking, and history of high blood pressure or diabetes were also associated with high global risk. Conclusions This prospective epidemiological study showed that the risk of clinically diagnosed imprinting-related diseases is increased in children conceived after fresh embryo transfers or from mothers with endometriosis. The increased perturbations in genomic imprinting could be caused by controlled ovarian hyperstimulation and potentially endometriosis through the impairment of endometrial receptivity and placentation, leading to epigenetic feto-placental changes. Further studies are now needed to improve understanding of the underlying molecular mechanisms (i.e. genetic or epigenetic causes).
- Subjects :
- 0301 basic medicine
Epigenomics
Male
medicine.medical_treatment
Endometriosis
Reproductive technology
Infant, Newborn, Diseases
Cohort Studies
0302 clinical medicine
Neonatal diabetes mellitus
Pregnancy
Risk Factors
Female infertility
Prospective Studies
Epigenetic diseases
Child
Children
Genetics (clinical)
030219 obstetrics & reproductive medicine
Obstetrics
Middle Aged
Embryo transfer
Female
France
Assisted reproductive technologies
Infertility, Female
Adult
medicine.medical_specialty
Reproductive Techniques, Assisted
Fertilization in Vitro
03 medical and health sciences
Genomic Imprinting
Genetics
medicine
Humans
Advanced maternal age
Molecular Biology
Singletons
In vitro fertilisation
business.industry
Research
Infant, Newborn
DNA Methylation
medicine.disease
Embryo Transfer
030104 developmental biology
Case-Control Studies
Genomic imprinting
business
Developmental Biology
Subjects
Details
- ISSN :
- 18687083
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical epigenetics
- Accession number :
- edsair.doi.dedup.....0d60abf5bdffa6909364b70eb1e481c1