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RETINAL FLUID AND THICKNESS AS MEASURES OF DISEASE ACTIVITY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
- Source :
- Retina (Philadelphia, Pa.)
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Retinal fluid and thickness are important anatomical features of disease activity in neovascular age-related macular degeneration. This review describes how these anatomical features relate to the visual acuity and the efficacy of dosing regimens that make use of these features for determining dosing interval durations.<br />Purpose: Retinal fluid and thickness are important anatomical features of disease activity in neovascular age-related macular degeneration, as evidenced by clinical trials that have used these features for inclusion criteria, retreatment criteria, and outcome measures of the efficacy of intravitreal injections of anti–vascular endothelial growth factor agents. Methods: A literature review of anatomical measures of disease activity was conducted. Results: Treatment goals for neovascular age-related macular degeneration include improving/maintaining vision by drying the retina, and several analyses have evaluated the relationship between visual function and anatomy. The change in retinal thickness has been found to correlate with the change in the visual acuity, and variation in retinal thickness may predict visual acuity outcomes. In addition, specific fluid compartments may have different prognostic values. For example, the presence of intraretinal fluid has been associated with poorer visual acuity, whereas the presence of subretinal fluid has been associated with better visual acuity. Retinal fluid and thickness are important for selecting dosing interval durations in clinical trials and clinical practice. Conclusion: Retinal thickness and retinal fluid are common anatomical measures of disease activity in neovascular age-related macular degeneration. Further research is required to fully elucidate the relationship between anatomical features and visual outcomes in neovascular age-related macular degeneration.
- Subjects :
- medicine.medical_specialty
Visual acuity
visual acuity
genetic structures
Fundus Oculi
Review
neovascular age-related macular degeneration
Severity of Illness Index
Disease activity
chemistry.chemical_compound
Ophthalmology
Age related
medicine
Humans
Fluorescein Angiography
intraretinal fluid
retinal thickness
Retina
business.industry
subretinal fluid
Retinal
General Medicine
Fluid compartments
Macular degeneration
Prognosis
medicine.disease
dosing
eye diseases
Clinical trial
medicine.anatomical_structure
chemistry
Wet Macular Degeneration
sense organs
medicine.symptom
business
disease activity
Tomography, Optical Coherence
subretinal pigment epithelium fluid
Subjects
Details
- ISSN :
- 0275004X
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Retina
- Accession number :
- edsair.doi.dedup.....0d5adb6e1002f7df20303e4c4b3e68ff