Low SP1 Expression Differentially Affects Intestinal-Type Compared with Diffuse-Type Gastric Adenocarcinoma

Authors :: Özgür Cem Erkin
Su-Yeon Lee
Yoon-La Choi
Hun Soon Jung
Mi-Hyun Cho
Ensel Oh
Seoung Wan Chae
Young Kee Shin
Mi Jeong Kwon
Lihui Wang
Seok-Hyung Kim
Lina Jia
Ho Bin Yang
Min-Jeong Park
Hun Seok Lee
Cheol-Keun Park
Source :: PLoS ONE, PLoS ONE, Vol 8, Iss 2, p e55522 (2013)
Publication Year :: 2013
Publisher :: Public Library of Science, 2013.
Abstract: Specificity protein 1 (SP1) is an essential transcription factor that regulates multiple cancer-related genes. Because aberrant expression of SP1 is related to cancer development and progression, we focused on SP1 expression in gastric carcinoma and its correlation with disease outcomes. Although patient survival decreased as SP1 expression increased (P

Subjects :: Male
Pathology
lcsh:Medicine
Metastasis
Cell Movement
Gene expression
Gastrointestinal Cancers
Intestinal Mucosa
lcsh:Science
Regulation of gene expression
Gene knockdown
Multidisciplinary
Cell migration
Middle Aged
Immunohistochemistry
Gene Expression Regulation, Neoplastic
Intestines
Cell Transformation, Neoplastic
Oncology
Adenocarcinoma
Medicine
Female
Molecular Pathology
Research Article
medicine.medical_specialty
Clinical Pathology
Sp1 Transcription Factor
Gastroenterology and Hepatology
Biology
Transfection
Diagnostic Medicine
Stomach Neoplasms
Cell Line, Tumor
Gastrointestinal Tumors
medicine
Genetics
Cancer Genetics
Humans
Neoplasm Invasiveness
Aged
Cell Proliferation
Microarray analysis techniques
lcsh:R
Cancer
Cancers and Neoplasms
medicine.disease
Survival Analysis
Gastric Cancer
Multivariate Analysis
Cancer research
lcsh:Q
General Pathology
Genes, Neoplasm

Tools