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Identification of Antiinflammatory Diterpenes from the Marine Gorgonian Pseudopterogorgia elisabethae
Identification of Antiinflammatory Diterpenes from the Marine Gorgonian Pseudopterogorgia elisabethae
- Source :
- ChemInform. 34
- Publication Year :
- 2003
- Publisher :
- Wiley, 2003.
-
Abstract
- Analysis of the terpene metabolites of Pseudopterogorgia elisabethae collected from the Florida Keys has resulted in the identification of a novel hydroxyquinone, elisabethadione (1), as well as new pseudopterosins and seco-pseudopterosins. Anti-inflammatory assays indicate that elisabethadione is more potent than the well characterized pseudopterosin A and E. This report also describes the co-occurrence of pseudopterosins and seco-pseudopterosins, diterpenes with amphilectane and serrulatane skeletons, respectively. This together with our previously described isolation of elisabethatriene as the sole diterpene cyclase product in P. elisabethae suggests that the amphilectane and serrulatane families of diterpenes are derived from the same geranylgeranyl diphosphate cyclase product.
- Subjects :
- Pseudopterosin A
food.ingredient
biology
Chemistry
Stereochemistry
Organic Chemistry
Elisabethatriene
General Medicine
Pseudopterogorgia
biology.organism_classification
Biochemistry
Cyclase
Terpene
chemistry.chemical_compound
Gorgonian
food
Drug Discovery
Identification (biology)
Diterpene
Hydroxyquinone
Subjects
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi.dedup.....0d3f012c8bfd27910eb4b846ff68b950
- Full Text :
- https://doi.org/10.1002/chin.200340176