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Identification of Antiinflammatory Diterpenes from the Marine Gorgonian Pseudopterogorgia elisabethae

Identification of Antiinflammatory Diterpenes from the Marine Gorgonian Pseudopterogorgia elisabethae

Authors :
Russell G. Kerr
Claudia Moya
Athar Ata
Robert S. Jacobs
Source :
ChemInform. 34
Publication Year :
2003
Publisher :
Wiley, 2003.

Abstract

Analysis of the terpene metabolites of Pseudopterogorgia elisabethae collected from the Florida Keys has resulted in the identification of a novel hydroxyquinone, elisabethadione (1), as well as new pseudopterosins and seco-pseudopterosins. Anti-inflammatory assays indicate that elisabethadione is more potent than the well characterized pseudopterosin A and E. This report also describes the co-occurrence of pseudopterosins and seco-pseudopterosins, diterpenes with amphilectane and serrulatane skeletons, respectively. This together with our previously described isolation of elisabethatriene as the sole diterpene cyclase product in P. elisabethae suggests that the amphilectane and serrulatane families of diterpenes are derived from the same geranylgeranyl diphosphate cyclase product.

Details

ISSN :
15222667 and 09317597
Volume :
34
Database :
OpenAIRE
Journal :
ChemInform
Accession number :
edsair.doi.dedup.....0d3f012c8bfd27910eb4b846ff68b950
Full Text :
https://doi.org/10.1002/chin.200340176