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Pregnancy outcomes and risk of endometrial cancer
- Source :
- Int J Cancer, International Journal of Cancer, 148(9), 2068-2078. Wiley
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- A full-term pregnancy is associated with reduced endometrial cancer risk; however, whether the effect of additional pregnancies is independent of age at last pregnancy is unknown. The associations between other pregnancy-related factors and endometrial cancer risk are less clear. We pooled individual participant data from 11 cohort and 19 case-control studies participating in the Epidemiology of Endometrial Cancer Consortium (E2C2) including 16 986 women with endometrial cancer and 39 538 control women. We used one- and two-stage meta-analytic approaches to estimate pooled odds ratios (ORs) for the association between exposures and endometrial cancer risk. Ever having a full-term pregnancy was associated with a 41% reduction in risk of endometrial cancer compared to never having a full-term pregnancy (OR = 0.59, 95% confidence interval [CI] 0.56-0.63). The risk reduction appeared the greatest for the first full-term pregnancy (OR = 0.78, 95% CI 0.72-0.84), with a further similar to 15% reduction per pregnancy up to eight pregnancies (OR = 0.20, 95% CI 0.14-0.28) that was independent of age at last full-term pregnancy. Incomplete pregnancy was also associated with decreased endometrial cancer risk (7%-9% reduction per pregnancy). Twin births appeared to have the same effect as singleton pregnancies. Our pooled analysis shows that, while the magnitude of the risk reduction is greater for a full-term pregnancy than an incomplete pregnancy, each additional pregnancy is associated with further reduction in endometrial cancer risk, independent of age at last full-term pregnancy. These results suggest that the very high progesterone level in the last trimester of pregnancy is not the sole explanation for the protective effect of pregnancy.
- Subjects :
- Cancer Research
medicine.medical_specialty
miscarriage
induced abortion
Article
Miscarriage
03 medical and health sciences
0302 clinical medicine
AGE
Pregnancy
Risk Factors
Epidemiology
medicine
Humans
HORMONE-BINDING GLOBULIN
REPRODUCTIVE FACTORS
sex of offspring
business.industry
Obstetrics
Endometrial cancer
Pregnancy Outcome
endometrial cancer
parity
WOMEN
Odds ratio
PROGESTERONE
medicine.disease
Confidence interval
Endometrial Neoplasms
3. Good health
ESTROGEN
Pooled analysis
Oncology
Case-Control Studies
030220 oncology & carcinogenesis
Cohort
Female
SEX
business
Subjects
Details
- Language :
- English
- ISSN :
- 10970215 and 00207136
- Volume :
- 148
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi.dedup.....0d3c15005ff55b84d1a1ccb6b38ff065