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Bioavailability of metronidazole in fasting and non-fasting healthy subjects and in patients with Crohn's disease
- Source :
- European journal of clinical pharmacology. 12(1)
- Publication Year :
- 1977
-
Abstract
- The possible influence of food intake on the bioavailability of metronidazole was examined in ten health volunteers by administration of a single dose of metronidazole on an empty stomach, and with a standardized breakfast. Food intake did not significantly alter the bioavailability of metronidazole. The interindividual variation in bioavailability appeared to be slight. In nine patients with Crohn's disease, the absorption of metronidazole appeared to be reduced and to be more variable than in healthy subjects. In both groups there was a clear relationship between the amount absorbed and dose/kg body weight. Thus, from the pharmacokinetic point of view, metronidazole can safely be given either with or between meals. The dose should be related to body weight.
- Subjects :
- Adult
Male
Food intake
medicine.medical_specialty
Biological Availability
Absorption (skin)
Pharmacology
Gastroenterology
Eating
Pharmacokinetics
Crohn Disease
Internal medicine
Metronidazole
Medicine
Humans
Pharmacology (medical)
Crohn's disease
Clinical Trials as Topic
business.industry
Stomach
digestive, oral, and skin physiology
Healthy subjects
General Medicine
Fasting
medicine.disease
Bioavailability
medicine.anatomical_structure
Female
business
medicine.drug
Half-Life
Subjects
Details
- ISSN :
- 00316970
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- European journal of clinical pharmacology
- Accession number :
- edsair.doi.dedup.....0d3bb8fa0239d63c658df48e15b70303