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Influenza in High-Risk Hosts—Lessons Learned from Animal Models
- Source :
- Cold Spring Harb Perspect Med
- Publication Year :
- 2020
- Publisher :
- Cold Spring Harbor Laboratory Press, 2020.
-
Abstract
- Factoring significantly into the global burden of influenza disease are high-risk populations that suffer the bulk of infections. Classically, the very young, very old, and pregnant women have been identified as high-risk populations; however, recent research has uncovered several other conditions that contribute to severe infection. By using varied animal models, researchers have identified molecular mechanisms underpinning the increased likelihood for infection due to obesity and malnourishment, as well as insight into the role sex hormones play in antiviral immunity in males, in females, and across the life span. Additionally, novel comorbidity models have helped elucidate the role of chronic infectious and genetic diseases in influenza virus pathogenesis. Animal models play a vital role in understanding the contribution of host factors to influenza severity and immunity. An in-depth understanding of these host factors represents an important step in reducing the burden of influenza among the growing number of people living with one or more chronic medical conditions.
- Subjects :
- 0301 basic medicine
Male
Host factors
Disease
Risk Assessment
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Antiviral immunity
Mice
Sex Factors
Immunity
Pregnancy
Influenza, Human
medicine
Animals
Humans
Life span
business.industry
medicine.disease
030112 virology
Comorbidity
Obesity
Malnutrition
Disease Models, Animal
030104 developmental biology
Influenza A virus
Immunology
Female
business
Perspectives
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Cold Spring Harb Perspect Med
- Accession number :
- edsair.doi.dedup.....0d3b4e1b4ac9491850119f8b23801ce7