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Delta Neutrophil Index as a Promising Prognostic Marker in Out ofHospital Cardiac Arrest
- Source :
- PLOS ONE(10): 3, PLoS ONE, Vol 10, Iss 3, p e0120677 (2015), PLoS ONE
- Publication Year :
- 2015
-
Abstract
- Background The post-resuscitation phase after out-of-hospital cardiac arrest (OHCA) is characterised by a systemic inflammatory response (e.g., severe sepsis), for which the immature granulocyte count is a diagnostic marker. In this study we evaluated the prognostic significance of the delta neutrophil index (DNI), which is the difference in leukocyte subfractions as assessed by an automated blood cell analyser, for early mortality after OHCA. Materials and Methods OHCA records from the emergency department cardiac arrest registry were retrospectively analysed. Patients who survived at least 24 h after return of spontaneous circulation were included in the analysis. We evaluated mortality and cerebral performance category scores at 30 days. Results A total of 83 patients with OHCA were included in the study. Our results showed that DNI >8.4% on day 1 (hazard ratio [HR], 3.227; 95% CI, 1.485–6.967; p = 0.001) and DNI >10.5% on day 2 (HR, 3.292; 95% CI, 1.662–6.519; p8.4% on day 1 (HR, 2.718; 95% CI, 1.508–4.899; p10.5% on day 2 (HR, 1.709; 95% CI, 1.051–2.778; p = 0.02) were associated with worse neurologic outcomes 30 days after OHCA. Conclusion A higher DNI is a promising prognostic marker for 30-day mortality and neurologic outcomes after OHCA. Our findings indicate that patients with elevated DNI values after OHCA might be closely monitored so that appropriate treatment strategies can be implemented.
- Subjects :
- Male
medicine.medical_specialty
Resuscitation
Neutrophils
medicine.medical_treatment
lcsh:Medicine
Kaplan-Meier Estimate
Out of hospital cardiac arrest
Sepsis
Blood cell
Internal medicine
medicine
Humans
Cardiopulmonary resuscitation
lcsh:Science
Aged
Retrospective Studies
Multidisciplinary
Immature Granulocyte Count
business.industry
lcsh:R
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
Cardiopulmonary Resuscitation
Surgery
Systemic inflammatory response syndrome
medicine.anatomical_structure
Cardiology
Female
lcsh:Q
business
Biomarkers
Out-of-Hospital Cardiac Arrest
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PLOS ONE(10): 3, PLoS ONE, Vol 10, Iss 3, p e0120677 (2015), PLoS ONE
- Accession number :
- edsair.doi.dedup.....0d2fc165bd1616b1bd8643b048b8c411