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Inorganic arsenic causes apoptosis cell death and immunotoxicity on European sea bass (Dicentrarchus labrax)
- Source :
- e-IEO: Repositorio Institucional Digital de Acceso Abierto del Instituto Español de Oceanografía, Instituto Español de Oceanografía, e-IEO. Repositorio Institucional Digital de Acceso Abierto del Instituto Español de Oceanografía, Universidad de Alicante (UA)
- Publication Year :
- 2018
- Publisher :
- Centro Oceanográfico de Murcia, 2018.
-
Abstract
- Inorganic arsenic (As) is one of the most toxic pollutants in the water. We have studied their effects on the marine teleost European sea bass (Dicentrarchus labrax) at 2 and 10 days of 5 μMofAs2O3 (sub-lethal doses) waterborne exposure. Arsenic accumulates in liver and gill tissues. The expression profile of five genes (bax, blc2, casp3, casp8 and casp9) involved in apoptosis cell death confirmed apoptotic effects in liver, slight changes in gill and no effects in skin according with the histopathology findings. Total IgM level and peroxidase activities were increased at 2 and 10 days, respectively. The bactericidal activity was decreased at 2 days after As exposure. A general decrease of cellular immune activities with significant differences in the case of respiratory burst activity was observed after 2 and 10 days of exposure. This work describes for the first time the effects of As exposure on European sea bass.<br />SI
- Subjects :
- 0301 basic medicine
Gills
Programmed cell death
Acuicultura
chemistry.chemical_element
Gene Expression
Apoptosis
Immunotoxicology
Aquatic Science
Oceanography
Arsenicals
Andrology
histology
03 medical and health sciences
Arsenic Trioxide
Phagocytosis
Animals
Centro Oceanográfico de Murcia
Sea bass
Arsenic
fish
European sea bass (Dicentrarchus labrax)
Immunity, Cellular
biology
arsenic
Aquatic animal
Oxides
biology.organism_classification
Pollution
Respiratory burst
marine pollution
030104 developmental biology
chemistry
Immunoglobulin M
Liver
cytology
Dicentrarchus
Bass
Water Pollutants, Chemical
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- e-IEO: Repositorio Institucional Digital de Acceso Abierto del Instituto Español de Oceanografía, Instituto Español de Oceanografía, e-IEO. Repositorio Institucional Digital de Acceso Abierto del Instituto Español de Oceanografía, Universidad de Alicante (UA)
- Accession number :
- edsair.doi.dedup.....0d2376d61c50d409e09b4d31f299182d