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Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study
- Source :
- Diabetes Care, Diabetes Care 39, 1535-1542 (2016)
- Publication Year :
- 2016
- Publisher :
- American Diabetes Association, 2016.
-
Abstract
- OBJECTIVE β-Cell autoantibodies are a feature of the preclinical phase of type 1 diabetes. Here, we asked how frequently they revert in a cohort of children at risk for type 1 diabetes and whether reversion has any effect on type 1 diabetes risk. RESEARCH DESIGN AND METHODS Children were up to 10 years of age and screened more than once for insulin autoantibody, GAD antibody, and insulinoma antigen-2 antibodies. Persistent autoantibody was defined as an autoantibody present on two or more consecutive visits and confirmed in two reference laboratories. Reversion was defined as two or more consecutive negative visits after persistence. Time-dependent Cox regression was used to examine how reversion modified the risk of development of multiple autoantibodies and type 1 diabetes. RESULTS Reversion was relatively frequent for autoantibodies to GAD65 (19%) and insulin (29%), but was largely restricted to children who had single autoantibodies (24%) and rare in children who had developed multiple autoantibodies ( CONCLUSIONS Type 1 diabetes risk remained high in children who had developed multiple β-cell autoantibodies even when individual autoantibodies reverted. We suggest that monitoring children with single autoantibodies for at least 1 year after seroconversion is beneficial for stratification of type 1 diabetes risk.
- Subjects :
- Male
0301 basic medicine
Genotype
Insulin Antibodies
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Autoimmunity
030209 endocrinology & metabolism
medicine.disease_cause
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Risk Factors
Insulin-Secreting Cells
Diabetes mellitus
Internal Medicine
Humans
Insulin
Medicine
Receptor-Like Protein Tyrosine Phosphatases, Class 8
Prospective Studies
Epidemiology/Health Services Research
Seroconversion
Child
Prospective cohort study
Autoantibodies
Advanced and Specialized Nursing
Type 1 diabetes
Glutamate Decarboxylase
business.industry
Autoantibody
medicine.disease
Diabetes Mellitus, Type 1
030104 developmental biology
Child, Preschool
Cohort
Immunology
Female
business
Subjects
Details
- ISSN :
- 19355548 and 01495992
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Diabetes Care
- Accession number :
- edsair.doi.dedup.....0d1e7767b1196db263df60faef843e56