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Preclinical Models for Skeletal Research: How Commonly Used Species Mimic (or Don’t) Aspects of Human Bone
- Source :
- Toxicologic Pathology. 45:851-854
- Publication Year :
- 2017
- Publisher :
- SAGE Publications, 2017.
-
Abstract
- Preclinical studies play an indispensable role in exploring the biological regulation of the musculoskeletal system. They are required in all drug development pipelines where both small and large animal models are needed to understand efficacy and side effects. This brief review highlights 4 aspects of human bone, longitudinal bone growth, intracortical remodeling, collagen/mineral interface, and age-related changes, and discusses how various animal models recapitulate (or don’t) these aspects of human skeletal physiology.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Musculoskeletal Physiological Phenomena
Human bone
030209 endocrinology & metabolism
Biology
Toxicology
Bone and Bones
Pathology and Forensic Medicine
Longitudinal bone growth
03 medical and health sciences
0302 clinical medicine
Animal model
medicine
Animals
Humans
Molecular Biology
Longitudinal growth
Cell Biology
Disease Models, Animal
030104 developmental biology
Drug development
Osteoporosis
Bone Remodeling
Collagen
Biological regulation
Neuroscience
Large animal
Subjects
Details
- ISSN :
- 15331601 and 01926233
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Toxicologic Pathology
- Accession number :
- edsair.doi.dedup.....0d1d7c837d9b177dd75851a2a6ca9721
- Full Text :
- https://doi.org/10.1177/0192623317733925