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Preclinical Models for Skeletal Research: How Commonly Used Species Mimic (or Don’t) Aspects of Human Bone

Authors :
Matthew R. Allen
Source :
Toxicologic Pathology. 45:851-854
Publication Year :
2017
Publisher :
SAGE Publications, 2017.

Abstract

Preclinical studies play an indispensable role in exploring the biological regulation of the musculoskeletal system. They are required in all drug development pipelines where both small and large animal models are needed to understand efficacy and side effects. This brief review highlights 4 aspects of human bone, longitudinal bone growth, intracortical remodeling, collagen/mineral interface, and age-related changes, and discusses how various animal models recapitulate (or don’t) these aspects of human skeletal physiology.

Details

ISSN :
15331601 and 01926233
Volume :
45
Database :
OpenAIRE
Journal :
Toxicologic Pathology
Accession number :
edsair.doi.dedup.....0d1d7c837d9b177dd75851a2a6ca9721
Full Text :
https://doi.org/10.1177/0192623317733925