Back to Search
Start Over
Brain Zinc Deficiency Exacerbates Cognitive Decline in the R6/1 Model of Huntington’s Disease
- Source :
- Neurotherapeutics
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- There is currently no disease-modifying treatment for Huntington’s disease (HD), which is characterized by chorea motor impairment and cognitive decline. The zinc ionophore, PBT2, was previously shown to improve the phenotype of a HD mouse model and reported efficacy in certain cognitive tests in a phase II clinical trial in HD. Here we report that zinc deficiency is a feature of the hippocampus and cortex in the R6/1 mouse model of HD. Low cortical zinc has been shown to induce cognitive impairment, and indeed, dietary restriction of zinc in R6/1 mice was associated with cognitive impairment in the Y-maze, an exacerbated hippocampal long-term potentiation (LTP) deficit and reduction of AMPA receptors (and not other glutamatergic receptors). These data reveal the importance of zinc in maintaining brain function in HD. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13311-019-00785-6) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Hippocampus
AMPA receptor
Receptors, N-Methyl-D-Aspartate
03 medical and health sciences
0302 clinical medicine
Huntington's disease
Internal medicine
medicine
Animals
Cognitive Dysfunction
Pharmacology (medical)
Receptors, AMPA
Cognitive decline
Maze Learning
Brain Chemistry
Neurons
Pharmacology
business.industry
Brain
Chorea
Long-term potentiation
medicine.disease
Mice, Inbred C57BL
Disease Models, Animal
Zinc
Huntington Disease
030104 developmental biology
Endocrinology
Zinc deficiency
Original Article
Female
Neurology (clinical)
medicine.symptom
PBT2
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18787479 and 19337213
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Neurotherapeutics
- Accession number :
- edsair.doi.dedup.....0d1b16191768e4363f6a14b2e9810564