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Language Processing and Human Voice Perception in Schizophrenia: A Functional Magnetic Resonance Imaging Study
- Source :
- Biological Psychiatry. 59:948-957
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Background Neuroimaging studies have demonstrated either reduced left-lateralized activation or reversed language dominance in schizophrenia. These findings of left hemispheric dysfunction could be attributed to language processing tasks, which activate mainly left hemispheric function. Recent functional magnetic resonance imaging studies reported right-lateralized temporal activation by human voice perception, but few studies have investigated activation by human voice in schizophrenia. We aimed to clarify the cerebral function of language processing in schizophrenia patients by considering cerebral activation of human voice perception. Methods Fourteen right-handed schizophrenia patients and 14 right-handed controls with matched handedness, sex, and education level were scanned by functional magnetic resonance imaging while listening to sentences (SEN), reverse sentences (rSEN), and identifiable non-vocal sounds (SND). Results Under the SEN-SND and SEN-rSEN contrasts including language processing, patients showed less activation of the left hemisphere than controls in the language-related fronto-tempo-parietal region, hippocampus, thalamus and cingulate gyrus. Under the rSEN-SND contrast including human voice perception, patients showed less activation than controls in the right-lateralized temporal cortices and bilateral posterior cingulate. Conclusions Our results indicate that schizophrenia patients have impairment of broader bilateral cortical-subcortical regions related to both the semantic network in the left hemisphere and the voice-specific network in the right hemisphere.
- Subjects :
- Adult
Male
medicine.medical_specialty
Psychosis
Sound Spectrography
Speech perception
Audiology
Sensitivity and Specificity
behavioral disciplines and activities
Brain mapping
Speech Acoustics
Lateralization of brain function
Imaging, Three-Dimensional
Neuroimaging
Image Processing, Computer-Assisted
medicine
Humans
Dominance, Cerebral
Biological Psychiatry
Cerebral Cortex
Brain Mapping
medicine.diagnostic_test
Brain
medicine.disease
Magnetic Resonance Imaging
Semantics
Functional imaging
Posterior cingulate
Schizophrenia
Speech Perception
Voice
Female
Nerve Net
Psychology
Functional magnetic resonance imaging
Cognitive psychology
Subjects
Details
- ISSN :
- 00063223
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Biological Psychiatry
- Accession number :
- edsair.doi.dedup.....0d13cdb2faa877df8b17930c438a0fb3