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Citation for a discussion of noncompliance
- Source :
- Lab Animal. 40:35-35
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Dr. Larry Covelli was proud of the IACUC he chaired at Great Eastern University. There was a culture of thorough but reasonable protocol reviews, open discussions at meetings and an honest effort to balance animal welfare with research requirements. Why, then, was he morose and bitter after talking to the IACUC Administrator? Unknown to the IACUC, an investigator without an IACUC protocol was given a single-needle biopsy sample taken from the liver of a sheep that was being used in a survival abdominal surgical procedure for an unrelated purpose. The sheep study did have IACUC approval, but the approval did not include the biopsy. The Principal Investigator (PI) of the sheep study thought he was just doing a favor for a colleague who needed a small sample of liver tissue. In fact, as was later learned, the PI thought he was reducing animal usage because his colleague would not have to use an entirely separate animal for the biopsy. As for the sheep, she recovered uneventfully. All of this occurred on a Monday, and by the next morning, Covelli knew of the incident. He quickly contacted both investigators, told them why they were noncompliant with NIH/OLAW policy and USDA/Animal Care regulations, and stated that no further biopsies were to be done without an approved protocol amendment or a new protocol. Coincidentally, the monthly IACUC meeting took place that Wednesday, and at the meeting, Covelli dutifully reported what had transpired. After a discussion, the committee concluded that the actions taken by Covelli were appropriate and voted to send a letter of explanation and reprimand to both investigators. Although the incident was a protocol noncompliance, the discussion and vote indicated it was not serious enough to inform NIH/OLAW of the incident and its resolution. Some months later, during a routine USDA/Animal Care inspection, the inspecting veterinarian read the minutes of the IACUC meeting during which the sheep
- Subjects :
- medicine.medical_specialty
Biomedical Research
Biopsy
Biopsy sample
United States Public Health Service
Animals, Laboratory
Liver tissue
Animal welfare
medicine
Animals
United States Department of Agriculture
Protocol (science)
Jurisprudence
Sheep
Animal Care Committees
General Veterinary
Approved Protocol
business.industry
Small sample
Mandatory Reporting
Organizational Policy
United States
Family medicine
Animal Science and Zoology
Guideline Adherence
Citation
business
Subjects
Details
- ISSN :
- 15484475 and 00937355
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Lab Animal
- Accession number :
- edsair.doi.dedup.....0d05d76266a73ada32bedad18eadda8d
- Full Text :
- https://doi.org/10.1038/laban0211-35a