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Genetic population structure of coagulase-negative staphylococci associated with carriage and disease in preterm infants
- Publication Year :
- 2016
-
Abstract
- Coagulase-negative staphylococci (CoNS) are a leading cause of sepsis in the neonatal intensive care unit (NICU) setting. To evaluate the hypothesis that isolates of CoNS associated with disease belong to hypervirulent clones, as opposed to being drawn randomly from the neonatal unit carriage flora, we conducted a prospective, case-controlled study in a busy NICU. Using pulsed-field gel electrophoresis (PFGE), we compared the population structures of CoNS isolates associated with bacteremia with isolates from the skin of healthy and infected neonates and with blood culture contaminants. Endemic clones of CoNS were identified, but there was no difference in the distribution of the 6 species or 73 PFGE types between the carriage and disease isolate groups; this suggests that hypervirulent clones with an enhanced ability to cause disease were not present in this NICU setting.
- Subjects :
- Microbiology (medical)
Coagulase
Male
Neonatal intensive care unit
Staphylococcus
Population
Bacteremia
Infant, Premature, Diseases
Microbiology
Intensive Care Units, Neonatal
Drug Resistance, Bacterial
medicine
Pulsed-field gel electrophoresis
Humans
Blood culture
Prospective Studies
education
education.field_of_study
medicine.diagnostic_test
business.industry
cons
Infant, Newborn
Genetic Variation
Staphylococcal Infections
medicine.disease
Anti-Bacterial Agents
Bacterial Typing Techniques
Electrophoresis, Gel, Pulsed-Field
Infectious Diseases
Carriage
Case-Control Studies
Female
business
Infant, Premature
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....0d04cbbac15d127658cf7970079b04bd