Back to Search
Start Over
Glycogen Synthase Kinase-3β: Variation over Time and the Possible Association with Mood and Cognition in Healthy Individuals
- Source :
- Neuropsychobiology. 73(2)
- Publication Year :
- 2015
-
Abstract
- Evidence indicates a role for glycogen synthase kinase-3β (GSK-3β) in the pathophysiology of mood disorders and in cognitive disturbances; however, the natural variation in GSK-3β activity over time is unknown. We aimed to investigate GSK-3β activity over time and its possible correlation with emotional lability, subjective mood fluctuations and cognitive function in healthy individuals. Thirty-seven healthy subjects were evaluated with neuropsychological tests and blood samples at baseline and 12-week follow-up. Total GSK-3β and serine-9-phosphorylated GSK-3β in peripheral blood mononuclear cells were quantitated using enzyme immunometric assays. The activity of GSK-3β (serine-9-phosphorylated GSK-3β/total GSK-3β) was lower at baseline compared with follow-up. No significant mean change over time was observed in levels of total GSK-3β and serine-9-phosphorylated GSK-3β. Exploratory analysis revealed lower activity of GSK-3β in spring and summer compared with the fall season. No correlation was observed between GSK-3β activity and emotional lability, subjective mood fluctuations or cognitive function. The results suggest that intra- and interindividual variation in GSK-3β activity over time could contribute to the heterogeneity of findings in clinical studies. The stability of GSK-3β activity and the role of potential moderators of GSK-3β activity warrant further investigation. Clinical studies of GSK-3β should consider including repeated measures of both cases and healthy individuals.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Adolescent
Physiology
macromolecular substances
Neuropsychological Tests
Affect (psychology)
Immunoenzyme Techniques
03 medical and health sciences
Young Adult
0302 clinical medicine
Cognition
medicine
Humans
Bipolar disorder
Longitudinal Studies
Phosphorylation
Psychiatry
Glycogen synthase
Biological Psychiatry
biology
Neuropsychology
Repeated measures design
Nuclear Proteins
Middle Aged
medicine.disease
030227 psychiatry
Psychiatry and Mental health
Affect
Cytoskeletal Proteins
Neuropsychology and Physiological Psychology
Mood
Mood disorders
biology.protein
Female
Seasons
Psychology
030217 neurology & neurosurgery
Blood Chemical Analysis
Follow-Up Studies
Subjects
Details
- ISSN :
- 14230224
- Volume :
- 73
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Neuropsychobiology
- Accession number :
- edsair.doi.dedup.....0d03d57ff0b154e8c531eb08f36e1091