Back to Search
Start Over
Immunoglobulin-binding domains of peptostreptococcal protein L enhance vaginal colonization of mice by Streptococcus gordonii
- Source :
- Microbial Pathogenesis. 30:229-235
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- Protein L, an immunoglobulin-binding protein of some strains of the anaerobic bacterium Peptostreptococcus magnus, has been hypothesized to be a virulence determinant in bacterial vaginosis. In order to investigate the role of protein L in peptostreptococcal virulence, the Ig-binding domains of protein L were expressed at the surface of the human oral commensal Streptococcus gordonii. Recombinant streptococci were used in vaginal colonization experiments, and protein L-expressing S. gordonii demonstrated enhanced ability to colonize the vaginal mucosa. Compared to the control strain, they also persisted for a longer period in the murine vagina.
- Subjects :
- Vaginal Diseases
Immunoglobulins
Virulence
Biology
Microbiology
Mice
Bacterial Proteins
stomatognathic system
Animals
Gram-Positive Bacterial Infections
Mice, Inbred BALB C
Binding Sites
Peptostreptococcus
Binding protein
Streptococcus gordonii
Streptococcus
biology.organism_classification
Streptococcaceae
Recombinant Proteins
Mice, Inbred C57BL
Disease Models, Animal
stomatognathic diseases
Protein L
Infectious Diseases
Genes, Bacterial
Vagina
biology.protein
Female
Antibody
Bacteria
Immunoglobulin binding
Subjects
Details
- ISSN :
- 08824010
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Microbial Pathogenesis
- Accession number :
- edsair.doi.dedup.....0cfe08b9c5f0dd7044ec991d49d2b462