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A Concise Review of Neurologic Complications Associated with Chimeric Antigen Receptor T-cell Immunotherapy
- Source :
- Neurologic Clinics. 38:953-963
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Chimeric antigen receptor-engineered T (CAR-T) cell immunotherapy has been successful in treating many types of hematological malignancies. CAR-T therapy, however, has been associated with toxicities, including cytokine release syndrome (CRS) as well as immune effector cell-associated neurotoxicity syndrome (ICANS). ICANS presentation is variable, largely reversible, and manifests with encephalopathy and focal neurologic deficits. Treatment strategies largely are supportive. ICANS pathophysiology likely is related to that of CRS. Preclinical studies and clinical experience have shed light on the driving forces of ICANS and have yielded new strategies to mitigate ICANS occurrence.
- Subjects :
- Neurotoxicity Syndrome
Receptors, Chimeric Antigen
business.industry
medicine.medical_treatment
Encephalopathy
Neurotoxicity
Immunotherapy
medicine.disease
Immunotherapy, Adoptive
Pathophysiology
Chimeric antigen receptor
03 medical and health sciences
Cytokine release syndrome
0302 clinical medicine
Antigen
Immunology
Humans
Medicine
Neurotoxicity Syndromes
030212 general & internal medicine
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 07338619
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Neurologic Clinics
- Accession number :
- edsair.doi.dedup.....0cfbf0ceccab9f23c37bc5ea05b16462