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Initial antimicrobial management of sepsis
- Source :
- Critical Care, CRITICAL CARE, Critical Care, Vol 25, Iss 1, Pp 1-11 (2021)
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- Sepsis is a common consequence of infection, associated with a mortality rate > 25%. Although community-acquired sepsis is more common, hospital-acquired infection is more lethal. The most common site of infection is the lung, followed by abdominal infection, catheter-associated blood steam infection and urinary tract infection. Gram-negative sepsis is more common than gram-positive infection, but sepsis can also be due to fungal and viral pathogens. To reduce mortality, it is necessary to give immediate, empiric, broad-spectrum therapy to those with severe sepsis and/or shock, but this approach can drive antimicrobial overuse and resistance and should be accompanied by a commitment to de-escalation and antimicrobial stewardship. Biomarkers such a procalcitonin can provide decision support for antibiotic use, and may identify patients with a low likelihood of infection, and in some settings, can guide duration of antibiotic therapy. Sepsis can involve drug-resistant pathogens, and this often necessitates consideration of newer antimicrobial agents.
- Subjects :
- Fungal infection
medicine.medical_specialty
Emergency Medical Services
INFECTIOUS-DISEASES SOCIETY
Urinary system
Bacteremia
Review
Critical Care and Intensive Care Medicine
Procalcitonin
CARE-ASSOCIATED PNEUMONIA
Antimicrobial therapy
Sepsis
Intra-abdominal infection
Medicine and Health Sciences
Medicine
Antimicrobial stewardship
Humans
Pharmacokinetics
Intensive care medicine
VENTILATOR-ASSOCIATED PNEUMONIA
CLINICAL-PRACTICE GUIDELINE
RC86-88.9
business.industry
Abdominal Infection
RESISTANT STAPHYLOCOCCUS-AUREUS
food and beverages
Medical emergencies. Critical care. Intensive care. First aid
COMMUNITY-ACQUIRED PNEUMONIA
Pneumonia
Antibiotic therapy
Antimicrobial
medicine.disease
Anti-Bacterial Agents
CAMPAIGN INTERNATIONAL GUIDELINES
Emergency Medical Technicians
Lactates
BETA-LACTAM ANTIBIOTICS
business
BLOOD-STREAM INFECTIONS
CRITICALLY-ILL PATIENTS
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 1466609X and 13648535
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Critical Care
- Accession number :
- edsair.doi.dedup.....0cef07a25cc95fc8cee2eecf89a1208b