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Efficacy of Alpinumisoflavone Isolated from Maclura tricuspidata Fruit in Tumor Necrosis Factor-α-Induced Damage of Human Dermal Fibroblasts
- Source :
- Antioxidants, Volume 10, Issue 4, Antioxidants, Vol 10, Iss 514, p 514 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- The skin is an important organ in the human body that protects the body from environmentally hazardous substances. Reactive oxygen species (ROS) cause inflammatory reactions and degradation of the extracellular matrix leading to skin aging and various cutaneous lesions. This study evaluated the potential of isoflavones isolated from Maclura tricuspidata fruit to prevent TNF-α-induced skin inflammation in normal human dermal fibroblasts (HDFs). It focused on alpinumisoflavone (AIF) that suppressed the accumulation of ROS and nitric oxide (NO) in tumor necrosis factor-alpha (TNF-α)-treated HDFs. AIF inhibited the TNF-α-induced increase in matrix metalloproteinase-1, decreased procollagen I α1, and suppressed pro-inflammatory mediators and pro-inflammatory cytokines, including NO synthase, cyclooxygenase-2, interleukin (IL)-1β, IL-6, and IL-8 that trigger inflammatory responses. AIF inhibited nuclear factor-κB and activating protein 1 mitogen-activated protein kinases that were increased by TNF-α stimulation. These results suggest that AIF may protect skin from aging and various cutaneous lesions.
- Subjects :
- 0301 basic medicine
human dermal fibroblasts
Physiology
Clinical Biochemistry
Inflammation
Pharmacology
Biochemistry
Article
Nitric oxide
Extracellular matrix
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Maclura tricuspidata
Molecular Biology
skin aging
Maclura tricuspidata fruit
chemistry.chemical_classification
Reactive oxygen species
alpinumisoflavone
biology
lcsh:RM1-950
Interleukin
ROS
Cell Biology
Alpinumisoflavone
biology.organism_classification
030104 developmental biology
lcsh:Therapeutics. Pharmacology
chemistry
030220 oncology & carcinogenesis
TNF-α
Tumor necrosis factor alpha
medicine.symptom
Subjects
Details
- Language :
- English
- ISSN :
- 20763921
- Database :
- OpenAIRE
- Journal :
- Antioxidants
- Accession number :
- edsair.doi.dedup.....0ce6dee29a89e8c4df2459ba6a65542a
- Full Text :
- https://doi.org/10.3390/antiox10040514