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Acute Neuroinflammation Promotes Cell Responses to 1800 MHz GSM Electromagnetic Fields in the Rat Cerebral Cortex
- Source :
- Neurotoxicity Research, Neurotoxicity Research, Springer Verlag, 2017, 32 (3), pp.444-459. 〈10.1007/s12640-017-9756-3〉, Neurotoxicity Research, Springer Verlag, 2017, 32 (3), pp.444-459. ⟨10.1007/s12640-017-9756-3⟩, Neurotoxicity Research, 2017, 32 (3), pp.444-459. ⟨10.1007/s12640-017-9756-3⟩
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- International audience; Mobile phone communications are conveyed by radiofrequency (RF) electromagnetic fields, including pulse-modulated global system for mobile communications (GSM)-1800 MHz, whose effects on the CNS affected by pathological states remain to be specified. Here, we investigated whether a 2-h head-only exposure to GSM-1800 MHz could impact on a neuroinflammatory reaction triggered by lipopolysaccharide (LPS) in 2-week-old or adult rats. We focused on the cerebral cortex in which the specific absorption rate (SAR) of RF averaged 2.9 W/kg. In developing rats, 24 h after GSM exposure, the levels of cortical interleukin-1ß (IL1ß) or NOX2 NADPH oxidase transcripts were reduced by 50 to 60%, in comparison with sham-exposed animals (SAR = 0), as assessed by RT-qPCR. Adult rats exposed to GSM also showed a 50% reduction in the level of IL1ß mRNA, but they differed from developing rats by the lack of NOX2 gene suppression and by displaying a significant growth response of microglial cell processes imaged in anti-Iba1-stained cortical sections. As neuroinflammation is often associated with changes in excitatory neurotransmission, we evaluated changes in expression and phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the adult cerebral cortex by Western blot analyses. We found that GSM exposure decreased phosphorylation at two residues on the GluA1 AMPAR subunit (serine 831 and 845). The GSM-induced changes in gene expressions, microglia, and GluA1 phosphorylation did not persist 72 h after RF exposure and were not observed in the absence of LPS pretreatment. Together, our data provide evidence that GSM-1800 MHz can modulate CNS cell responses triggered by an acute neuroinflammatory state.
- Subjects :
- 0301 basic medicine
Lipopolysaccharides
Male
Neuroimmunomodulation
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Interleukin-1beta
Lipopolysaccharide
Toxicology
[ SDV.NEU.PC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
03 medical and health sciences
[ SDV.NEU.SC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
0302 clinical medicine
Neuroinflammation
Animals
RNA, Messenger
Receptors, AMPA
AMPA receptor
Rats, Wistar
Cerebral Cortex
Inflammation
Neurons
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
General Neuroscience
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Electromagnetic fields
Disease Models, Animal
030104 developmental biology
Radiofrequency
[ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Acute Disease
NADPH Oxidase 2
Microglia
Mobile phone
030217 neurology & neurosurgery
Cell Phone
Subjects
Details
- Language :
- English
- ISSN :
- 10298428
- Database :
- OpenAIRE
- Journal :
- Neurotoxicity Research, Neurotoxicity Research, Springer Verlag, 2017, 32 (3), pp.444-459. 〈10.1007/s12640-017-9756-3〉, Neurotoxicity Research, Springer Verlag, 2017, 32 (3), pp.444-459. ⟨10.1007/s12640-017-9756-3⟩, Neurotoxicity Research, 2017, 32 (3), pp.444-459. ⟨10.1007/s12640-017-9756-3⟩
- Accession number :
- edsair.doi.dedup.....0ce55d87868778bafcfb05201e8fee24