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The genotype nucleophosmin mutated andFLT3-ITD negative is characterized by high bax/bcl-2 ratio and favourable outcome in acute myeloid leukaemia
- Source :
- British Journal of Haematology. 149:383-387
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Nucleophosmin gene (NPM1) mutations characterize acute myeloid leukaemia (AML) with normal karyotype and frequently co-exist with FLT3 internal tandem duplications (ITD). We evaluated bcl-2, bax, NPM1 and FLT3-ITD in 222 AML patients. Bax/bcl-2 ratio >0.35 and NPM1 without FLT3-ITD were significantly associated (P = 0.0001). NPM1-mutated (mt)/FLT3-ITD negative patients showed a higher complete remission (CR) rate (90%, P = 0.0002) and a longer overall survival (OS, P = 0.00007). NPM1-mt/FLT3-ITD negative plus bax/bcl-2 > 0.35 subset showed a very high CR rate (96%), very long OS (P = 0.00005) and disease-free survival (P = 0.004). The favourable prognosis of NPM1-mt/FLT3-ITD negative patients might be explained by a higher bax/bcl-2 ratio.
- Subjects :
- Myeloid
Male
medicine.medical_specialty
NPM1
Acute
Biology
hemic and lymphatic diseases
Internal medicine
Genotype
Biomarkers, Tumor
medicine
Humans
Tumor Markers
Prognosis
Retrospective Studies
bcl-2-Associated X Protein
Middle Aged
Mutation
Proto-Oncogene Proteins c-bcl-2
Female
Survival Analysis
fms-Like Tyrosine Kinase 3
Nuclear Proteins
Tumor Markers, Biological
Leukemia, Myeloid, Acute
Tandem Repeat Sequences
Survival analysis
Nucleophosmin
Leukemia
Hematology
Cancer
Biological
medicine.disease
body regions
medicine.anatomical_structure
embryonic structures
Cancer research
Settore MED/15 - Malattie del Sangue
psychological phenomena and processes
Subjects
Details
- ISSN :
- 13652141 and 00071048
- Volume :
- 149
- Database :
- OpenAIRE
- Journal :
- British Journal of Haematology
- Accession number :
- edsair.doi.dedup.....0ccf7353102dbb5ccfb9a4c2e8c6f453