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Regulation of Uterine Spiral Artery Remodeling: a Review
- Source :
- Reproductive Sciences
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Extravillous trophoblast remodeling of the uterine spiral arteries is essential for promoting blood flow to the placenta and fetal development, but little is known about the regulation of this process. A defect in spiral artery remodeling underpins adverse conditions of human pregnancy, notably early-onset preeclampsia and fetal growth restriction, which result in maternal and fetal morbidity and mortality. Many in vitro studies have been conducted to determine the ability of growth and other factors to stimulate trophoblast cells to migrate across a synthetic membrane. Clinical studies have investigated whether the maternal levels of various factors are altered during abnormal human pregnancy. Animal models have been established to assess the ability of various factors to recapitulate the pathophysiological symptoms of preeclampsia. This review analyzes the results of the in vitro, clinical, and animal studies and describes a nonhuman primate experimental paradigm of defective uterine artery remodeling to study the regulation of vessel remodeling.
- Subjects :
- Uterine artery remodeling
0301 basic medicine
Spiral artery
Placenta
Vascular Remodeling
030204 cardiovascular system & hematology
Bioinformatics
Preeclampsia
03 medical and health sciences
0302 clinical medicine
Pre-Eclampsia
Pregnancy
medicine.artery
medicine
Animals
Humans
Uterine artery
Fetus
business.industry
Uterus
Obstetrics and Gynecology
Trophoblast
medicine.disease
Animal models
Uterine Artery
030104 developmental biology
medicine.anatomical_structure
embryonic structures
Original Article
Female
Animal studies
business
Subjects
Details
- ISSN :
- 19337205 and 19337191
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Reproductive Sciences
- Accession number :
- edsair.doi.dedup.....0ccf53bcff72c41a98b6e486b8415185