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Relief of vasomotor symptoms and vaginal atrophy with three doses of conjugated estrogens and medroxyprogesterone acetate in postmenopausal Asian women from 11 countries: The Pan-Asia menopause (PAM) study
- Source :
- Maturitas. 52:35-51
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Objective: To evaluate the efficacy of three doses of estrogen/progestin therapy for relief of vasomotor symptoms (VMS) and vaginal atrophy in Asian women of different ethnic background; to examine differences in prevalence of VMS among ethnic groups. Methods: A prospective, randomized, double-blind multinational clinical trial in healthy postmenopausal women from 11 Asian countries. Following 2 weeks of baseline observations, the women received one of three conjugated estrogens (CE)/medroxyprogesterone acetate (MPA) doses (in mg) daily for 24 weeks: 0.625/2.5; 0.45/1.5; or 0.3/1.5. The women recorded VMS and uterine bleeding daily on diary cards translated into 10 languages. Vaginal responsiveness was evaluated by the vaginal maturation index (VMI) at baseline and at week 24. Results: The study population consisted of 1028 postmenopausal women. The VMS-evaluable subpopulation was about 60% of the total population. The mean baseline hot flush frequency was 1.6 flushes/day (613 women). Hot flush frequency decreased significantly in all dose groups within 4 weeks of treatment. The VMI shifted significantly from immature (parabasal) to mature (superficial) cells at end of treatment. The therapeutic responses were comparable in all three groups. However, uterine bleeding was consistently less frequent in the 0.3/1.5 mg group. The percentage of women who reported VMS at baseline differed substantially among the different ethnic groups, ranging from 5% in Indonesian women to 100% in Vietnamese women. Conclusion: Asian postmenopausal women respond to CE/MPA therapy. The lowest dose is as effective for VMS and vaginal responsiveness as the higher doses, and the lowest dose is associated with the most favorable bleeding pattern. The prevalence of vasomotor symptoms differs among ethnic groups.
- Subjects :
- Adult
medicine.medical_specialty
Asia
medicine.medical_treatment
Medroxyprogesterone
Vaginal Diseases
Administration, Oral
Medroxyprogesterone Acetate
Severity of Illness Index
Drug Administration Schedule
General Biochemistry, Genetics and Molecular Biology
Vaginal disease
Asian People
Double-Blind Method
medicine
Humans
Medroxyprogesterone acetate
Prospective Studies
Aged
Gynecology
Estrogens, Conjugated (USP)
Vasomotor
Obstetrics
business.industry
Estrogen Replacement Therapy
Obstetrics and Gynecology
Hormone replacement therapy (menopause)
Middle Aged
medicine.disease
Postmenopause
Menopause
Treatment Outcome
medicine.anatomical_structure
Hot Flashes
Vagina
Female
Vaginal atrophy
business
medicine.drug
Subjects
Details
- ISSN :
- 03785122
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Maturitas
- Accession number :
- edsair.doi.dedup.....0ccaf4dad41e2256a0acccfca4beff45