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Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia
- Source :
- PLoS ONE, Vol 12, Iss 1, p e0170545 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buffered saline. Flow cytometric analysis of immune responses revealed no persistent immunological alterations. Given its safety caffeine emerges as a candidate for neuroprotective intervention after neonatal brain injury.
- Subjects :
- 0301 basic medicine
Infarction
lcsh:Medicine
Pharmacology
Pathology and Laboratory Medicine
Mice
chemistry.chemical_compound
Spectrum Analysis Techniques
0302 clinical medicine
Medicine and Health Sciences
Brain Damage
lcsh:Science
Neurons
Mammals
Multidisciplinary
Animal Behavior
Flow Cytometry
Chemistry
Neuroprotective Agents
Treatment Outcome
Neurology
Spectrophotometry
Research Design
Anesthesia
Hypoxia-Ischemia, Brain
Physical Sciences
Vertebrates
Cytophotometry
medicine.symptom
Caffeine
Research Article
Clinical Research Design
Brain damage
Research and Analysis Methods
Rodents
Neuroprotection
03 medical and health sciences
Alkaloids
Signs and Symptoms
Atrophy
Immune system
Diagnostic Medicine
medicine
Animals
Humans
Adverse effect
Behavior
Dose-Response Relationship, Drug
business.industry
Brain morphometry
lcsh:R
Chemical Compounds
Organisms
Biology and Life Sciences
medicine.disease
Disease Models, Animal
030104 developmental biology
Animals, Newborn
chemistry
Amniotes
lcsh:Q
Adverse Events
business
Zoology
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....0cbf5caafaf51ac7ca607e6c9206d283