Back to Search
Start Over
Neutralization of Reactive Oxygen Species at Dinuclear Cu(II)-Cores: Tuning the Antioxidant Manifold in Water by Ligand Design
- Source :
- ACS Catalysis. 10:7295-7306
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- Dinuclear Cu-2(II,II)-cores stabilized by the N3O donorset of HL1 = (2-{[[di(2-pyridyl)methyl](methyl)amino]methyl}phenol), HL2 = 2-({[di(2-pyridyl)methyl] amino}methyl)phenol), and HL3 = 2-({[di(2-pyridyl)methyl]amino}methyl)-4-nitrophenol display a unique superoxide dismutase (SOD) combined with catalase (CAT)-like activity in water, at neutral pH. The Cu2L21 < Cu2L22 < Cu2L23 structure-reactivity trend puts a spotlight on the electron-deficient core of Cu2L23 that exhibits the highest SOD (log k(cat) (O-2(center dot-)) = 7.55) and CAT-like (k(H2O2) = 0.66 M(-1)s(-1)) performance. Time-lapse ESI-MS and EPR experiments indicate that a dimeric core is essential for oxygenic turnover upon H2O2 decomposition.
- Subjects :
- Antioxidant
medicine.medical_treatment
010402 general chemistry
01 natural sciences
Medicinal chemistry
Catalysis
Neutralization
antioxidant catalysis
Superoxide dismutase
chemistry.chemical_compound
parasitic diseases
medicine
Phenol
heterocyclic compounds
chemistry.chemical_classification
artificial enzyme
Reactive oxygen species
copper catalysis
biology
010405 organic chemistry
Chemistry
Ligand
copper catalysi
organic chemicals
catalase
General Chemistry
superoxide dismutase
artificial enzymes
0104 chemical sciences
artificial enzymes, copper catalysis, superoxide dismutase, catalase
Catalase
biology.protein
Subjects
Details
- ISSN :
- 21555435
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- ACS Catalysis
- Accession number :
- edsair.doi.dedup.....0cb473b22aaf25f3036d14be8b1fa244