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GATA3 is essential for separating patterning domains during facial morphogenesis
- Source :
- Development
- Publication Year :
- 2021
- Publisher :
- The Company of Biologists Ltd, 2021.
-
Abstract
- Neural crest cells (NCCs) within the mandibular and maxillary prominences of the first pharyngeal arch are initially competent to respond to signals from either region. However, mechanisms that are only partially understood establish developmental tissue boundaries to ensure spatially correct patterning. In the ‘hinge and caps’ model of facial development, signals from both ventral prominences (the caps) pattern the adjacent tissues whereas the intervening region, referred to as the maxillomandibular junction (the hinge), maintains separation of the mandibular and maxillary domains. One cap signal is GATA3, a member of the GATA family of zinc-finger transcription factors with a distinct expression pattern in the ventral-most part of the mandibular and maxillary portions of the first arch. Here, we show that disruption of Gata3 in mouse embryos leads to craniofacial microsomia and syngnathia (bony fusion of the upper and lower jaws) that results from changes in BMP4 and FGF8 gene regulatory networks within NCCs near the maxillomandibular junction. GATA3 is thus a crucial component in establishing the network of factors that functionally separate the upper and lower jaws during development.
- Subjects :
- Gene regulatory network
Morphogenesis
GATA3 Transcription Factor
Mandible
Biology
Syngnathia
Craniofacial Abnormalities
Mice
FGF8
medicine
Maxilla
Animals
Molecular Biology
Body Patterning
Cell Proliferation
First pharyngeal arch
Cell Death
GATA3
Neural crest
Gene Expression Regulation, Developmental
Anatomy
medicine.disease
Embryo, Mammalian
Hemifacial microsomia
medicine.anatomical_structure
Branchial Region
Neural Crest
Face
Developmental Biology
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Development
- Accession number :
- edsair.doi.dedup.....0cb3ffff1901854226962ff01ac6281d