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Physical Interaction of Mammalian CDC37 with CDK4
- Source :
- Journal of Biological Chemistry. 271:22030-22034
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- CDC37 was originally identified as a Start gene in budding yeast and has been shown to be required for association of CDC28 with cyclins. The exact functional mechanism by which CDC37 promotes this association, however, remains unknown. CDK4 is a cyclin D-dependent kinase that controls progression through G1 of the mammalian cell cycle. We have detected a specific association of CDK4 with the molecular chaperon HSP90 and a 44-kDa protein that we identify as mammalian CDC37. A physical interaction between CDC37 and CDK4 suggests that CDC37 may regulate the mammalian cell cycle through a direct effect on CDK4. Association of CDK4 with both CDC37 and HSP90 may also imply a mechanistic link between the functions of CDC37 and HSP90.
- Subjects :
- endocrine system diseases
Molecular Sequence Data
Cell Cycle Proteins
Biology
Biochemistry
Proto-Oncogene Proteins
Sequence Homology, Nucleic Acid
Mammalian cell
Animals
Drosophila Proteins
Amino Acid Sequence
HSP90 Heat-Shock Proteins
neoplasms
Molecular Biology
Gene
Cyclin
Genetics
Cyclin-dependent kinase 1
Base Sequence
Sequence Homology, Amino Acid
integumentary system
Kinase
Cyclin-Dependent Kinase 4
DNA
Cell Biology
Physical interaction
Hsp90
Cyclin-Dependent Kinases
Cell biology
Molecular Weight
CDC37
biology.protein
Electrophoresis, Polyacrylamide Gel
biological phenomena, cell phenomena, and immunity
Molecular Chaperones
Subjects
Details
- ISSN :
- 00219258
- Volume :
- 271
- Database :
- OpenAIRE
- Journal :
- Journal of Biological Chemistry
- Accession number :
- edsair.doi.dedup.....0ca9c7589e2c3b675b8558fcfd06f684