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An evolution in switching therapy for psoriasis patients who fail to meet treatment goals
- Source :
- Dermatologic Therapy
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- Switching psoriasis treatment is a common, accepted practice that is used to improve disease management and improve patient outcomes (e.g., when patients are experiencing suboptimal efficacy and/or tolerability with a given therapy). Historically, switching treatment was often performed to limit patients’ cumulative exposure to conventional systemic agents (e.g., methotrexate, cyclosporine) with the goal of reducing end‐organ toxicity. However, the practice of switching treatments has evolved in recent years with the availability of highly effective and tolerable biologic agents. In current practice, near‐complete skin clearance with minimal side effects should be a realistic treatment goal for most patients with moderate‐to‐severe psoriasis, and consideration for switching therapies has shifted to become more focused on achieving maximum possible skin clearance, enhanced quality of life, and improved patient satisfaction. This review provides a discussion of recent guidance on switching psoriasis therapies, including initial considerations for when switching therapy may be advisable and challenges associated with switching therapy, along with an overview of published clinical studies evaluating outcomes associated with switching therapy. The goal of this review is to empower dermatologists to optimally manage their patients’ psoriasis by providing the tools needed to develop rational strategies for switching treatments based on the pharmacologic characteristics of available treatments and each patient's clinical needs and treatment preferences.
- Subjects :
- medicine.medical_specialty
efficacy
Review Article
Dermatology
Treatment goals
Severity of Illness Index
Patient Care Planning
Medication Adherence
Patient satisfaction
Quality of life (healthcare)
Risk Factors
Psoriasis
medicine
Humans
Treatment Failure
Disease management (health)
Intensive care medicine
Skin
switching
Drug Substitution
business.industry
Remission Induction
psoriasis
General Medicine
medicine.disease
disease management
Tolerability
Patient Satisfaction
Current practice
strategies
Quality of Life
Physical therapy
treatment goals
Dermatologic Agents
business
Psoriasis treatment
Subjects
Details
- ISSN :
- 15298019 and 13960296
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Dermatologic Therapy
- Accession number :
- edsair.doi.dedup.....0ca2b4a42b4bc8b6112e76b48ff7a36c