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Cell Death of Human Polymorphonuclear Neutrophils Induced by a Pseudomonas aeruginosa Cystic Fibrosis Isolate Requires a Functional Type III Secretion System
- Source :
- Europe PubMed Central
- Publication Year :
- 1999
- Publisher :
- American Society for Microbiology, 1999.
-
Abstract
- With a coincubation model incorporating Pseudomonas aeruginosa and human polymorphonuclear neutrophils (PMNs), a cystic fibrosis (CF) P. aeruginosa isolate has been shown to resist the bactericidal action of PMNs and to induce their cellular death. An isogenic mutant of this CF isolate in which the type III secretion system was rendered nonfunctional was unable to induce cellular death of PMNs.
- Subjects :
- Blood Bactericidal Activity
Programmed cell death
Cystic Fibrosis
Neutrophils
Neutrophile
Immunology
Biology
Granulocyte
medicine.disease_cause
Microbiology
Cystic fibrosis
Type three secretion system
medicine
Humans
Secretion
Cell Death
Cytotoxins
Pseudomonas aeruginosa
hemic and immune systems
medicine.disease
Infectious Diseases
medicine.anatomical_structure
Molecular and Cellular Pathogenesis
Parasitology
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 10985522 and 00199567
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Infection and Immunity
- Accession number :
- edsair.doi.dedup.....0c9f735ea1defdcb1d6bb96d77113a3a