Back to Search
Start Over
Ictal Electroencephalographic Correlates of Posttreatment Neuropsychological Changes in Electroconvulsive Therapy
- Source :
- The Journal of ECT. 23:163-168
- Publication Year :
- 2007
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2007.
-
Abstract
- Objectives Electroconvulsive therapy (ECT) has been associated with memory and neuropsychological changes, but which features of ECT are associated with those changes have not been well investigated. The aim of this hypothesis-generation study was to examine correlations between ictal electroencephalographic (EEG) characteristics and cognitive side effects after ECT. Methods Eight patients with major depressive disorder were examined with the Wechsler Memory Scale-Revised (WMS-R), the Stroop test, the Trail Making Test, and verbal fluency before and after ECT treatment. Seven ictal EEG measurements (eg, slow-wave phase amplitude, postictal suppression) were manually rated by 3 independent psychiatrists. The correlations between ictal EEG measurements, changes in WMS-R subset scores, and non-memory-related neuropsychological assessments were examined with Spearman rank correlation. Results Verbal memory, general memory, attention/concentration, delayed memory of WMS-R subset scores, and the Stroop test scores improved significantly after ECT treatment. Postictal suppression and slow-wave amplitude correlated positively with delayed memory and visual/verbal discrepancy score. Slow-wave amplitude correlated negatively with letter fluency. The longer the polyspike wave duration, the higher the attention/concentration test results. Conclusions Certain ictal EEG measurements were associated with changes in several neuropsychological test results that had improved 2 weeks after the final ECT treatment. A hypothesis-testing study with a larger sample is needed to verify the relationships between EEG measurements and neuropsychological test performance.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Trail Making Test
Neuroscience (miscellaneous)
Neuropsychological Tests
Audiology
behavioral disciplines and activities
Electroconvulsive therapy
Visual memory
Memory
mental disorders
medicine
Humans
Verbal fluency test
Attention
Ictal
Electroconvulsive Therapy
Psychiatry
Depressive Disorder, Major
medicine.diagnostic_test
Electroencephalography
Neuropsychological test
Middle Aged
Psychiatry and Mental health
Female
Verbal memory
Psychology
Stroop effect
Subjects
Details
- ISSN :
- 10950680
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- The Journal of ECT
- Accession number :
- edsair.doi.dedup.....0c915e79074d07fc98caf169be816a3d