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FDG-avid presacral soft tissue mass in previously treated rectal cancer
- Source :
- EJSO, 45(4), 606-612. ELSEVIER SCI LTD
- Publication Year :
- 2019
- Publisher :
- ELSEVIER SCI LTD, 2019.
-
Abstract
- Introduction: This study aimed to determine the positive predictive value (PPV) of positron emission tomography/computed tomography (PET/CT) with an F-18-fluoro-2-deoxy-D-glucose (FDG)-avid presacral lesion for locally recurrent rectal cancer, and the additional value of magnetic resonance imaging (MRI), including diffusion-weighted imaging (DWI).Materials and methods: This retrospective study included 38 patients who completed primary rectal cancer treatment and who presented with a suspicious FDG-avid presacral lesion on PET/CT. Twenty-seven patients also underwent MRI, of whom 24 with DWI. PPV of FOG-PET/CT and additional value of MRI, including DWI, for the diagnosis of recurrent presacral cancer were determined.Results: The PPV of PET/CT with an FDG-avid presacral lesion for the diagnosis of locally recurrent rectal cancer was 58% (22/38). Air in the FDG-avid presacral lesion, as visible on the a component of the PET/CT examination, favoured the diagnosis of benign presacral tissue with a sensitivity of 56.3% (9/16) and a specificity 81.8% (18/22). Areas under the receiver operating characteristic curve (AUCs) of MRI without DWI for the diagnosis of locally recurrent rectal cancer in FDG-avid presacral tissue were 0.765 and 0.840, for observers 1 and 2. AUCs of MRI with DWI were 0.803 and 0.811, for observers 1 and 2. There were no significant differences among any of these AUCs (P=0.169 to 0.906).Conclusions: FOG-PET/CT has a poor PPV for locally recurrent rectal cancer in the presacral space. The observation of air in the FDG-avid presacral lesion and additional MRI assessment are diagnostically helpful, without a significant additional value of DWI. (C) 2018 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
- Subjects :
- Male
Colorectal cancer
Soft Tissue Neoplasms
030218 nuclear medicine & medical imaging
0302 clinical medicine
Positron Emission Tomography Computed Tomography
Presacral space
Rectal cancer
Aged, 80 and over
Proctectomy
medicine.diagnostic_test
General Medicine
Middle Aged
Oncology
Positron emission tomography
Area Under Curve
030220 oncology & carcinogenesis
Predictive value of tests
Female
Radiology
Adult
Sacrum
medicine.medical_specialty
PET/CT
PET-CT
Adenocarcinoma
Diffusion MRI
03 medical and health sciences
Magnetic resonance imaging
Fluorodeoxyglucose F18
Predictive Value of Tests
medicine
Humans
RECURRENCE
Aged
Retrospective Studies
Rectal Neoplasms
business.industry
Cancer
Chemoradiotherapy, Adjuvant
medicine.disease
18F-FDG
Diffusion Magnetic Resonance Imaging
ROC Curve
PATTERNS
Surgery
Neoplasm Recurrence, Local
Radiopharmaceuticals
business
Subjects
Details
- Language :
- English
- ISSN :
- 15322157 and 07487983
- Volume :
- 45
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- European Journal of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....0c887db9809ab8a7edba0d764f8e4410