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Chronic myelomonocytic leukemia with antecedent refractory anemia with excess blasts: Further evidence for the arbitrary nature of current classification systems
- Source :
- Leukemia & Lymphoma. 49:1292-1296
- Publication Year :
- 2008
- Publisher :
- Informa UK Limited, 2008.
-
Abstract
- From a retrospective analysis of our series of myelodysplastic patients, we found 16 patients who were initially diagnosed as having a refractory anemia with excess of blasts (RAEB) according to FAB criteria, but later on (median time 4 months, range 2-8) developed a peripheral monocytosis1 x 10(9)/L, leading to a disease re-classification into a dysplastic type of chronic myelomonocytic leukemia (MD-CMML). Analysis of clinical and prognostic aspects in this subgroup of patients as compared with those of primarily diagnosed MD-CMML patients, showed some significant differences in Hb level, platelet count, percentage of immature circulating precursor (IPC), bone marrow blastosis and trilineage dysplasia. Median survival for present group of patients was 33 months compared with 20 months for MD-CMML. Different prognostic scores were applied for evaluation of risk distribution and relative impact on survival prediction. We suggest on a possible atypical presentation of CMML and indicate a careful attention to be addressed to myelodysplastic patients who develop peripheral monocytosis, who might have a CMML variant, with more favourable prognosis and prolonged survival. Furthermore, we believe this is a further evidence for the arbitrary nature of current classification systems, which definitely exclude CMML from myelodysplastic syndromes.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Pathology
Refractory anemia
Chronic myelomonocytic leukemia
Bone Marrow Cells
Disease
World Health Organization
Gastroenterology
Monocytosis
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Platelet
Aged
Retrospective Studies
Anemia, Refractory, with Excess of Blasts
business.industry
chronic myelomocytic leukemia
refractory anemia with excess blasts
survival
survival read more: http://informahealthcare.com/doi/abs/10.1080/10428190802123499
who
Leukemia, Myelomonocytic, Chronic
Hematology
Middle Aged
Prognosis
medicine.disease
Survival Rate
medicine.anatomical_structure
Oncology
Dysplasia
Myelodysplastic Syndromes
Disease Progression
Female
Bone marrow
Refractory anemia with excess of blasts
business
Subjects
Details
- ISSN :
- 10292403 and 10428194
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Leukemia & Lymphoma
- Accession number :
- edsair.doi.dedup.....0c759a4f437f27fa7052abaec20f1dc9