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Hair growth-promoting activities of chitosan and surface-deacetylated chitin nanofibers
- Source :
- International Journal of Biological Macromolecules. 126:11-17
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- In this study, the effects of chitosan and surface-deacetylated chitin nanofibrils (SDACNFs) on hair growth were evaluated. In human follicle dermal papilla cells in vitro, chitosan and SDACNFs were shown to increase cell growth on day 3 after the initiation of treatment, together with an increase in the production of fibroblast growth factor-7 (FGF-7) by these cells on day 3. Furthermore, in an in vivo study in mice, chitosan and SDACNF application promoted hair growth. The number of anagen follicles significantly increased compared with that in the control group, whereas the number of telogen follicles significantly decreased in the chitosan and SDACNF groups. In the chitosan and SDACNFs groups, moreover, the expression levels of FGF-7 and Sonic hedgehog were significantly upregulated in hair follicles. Overall, our results demonstrated that chitosan and SDACNFs promoted hair growth and therefore may have applications as novel therapeutic agents for the treatment of hair loss in patients.
- Subjects :
- Surface Properties
Nanofibers
Chitin
macromolecular substances
02 engineering and technology
Biochemistry
Chitosan
03 medical and health sciences
chemistry.chemical_compound
Structural Biology
In vivo
medicine
Animals
Humans
Hedgehog Proteins
Molecular Biology
Cell Proliferation
030304 developmental biology
0303 health sciences
integumentary system
Cell growth
technology, industry, and agriculture
Acetylation
General Medicine
021001 nanoscience & nanotechnology
Hair follicle
medicine.disease
Cell biology
Mice, Inbred C57BL
carbohydrates (lipids)
Dermal papillae
medicine.anatomical_structure
Hair loss
chemistry
Fibroblast Growth Factor 7
Intercellular Signaling Peptides and Proteins
0210 nano-technology
Hair Follicle
Hair
Subjects
Details
- ISSN :
- 01418130
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Macromolecules
- Accession number :
- edsair.doi.dedup.....0c74a63c3539d0a8697b7b7d908c7386