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Amelioration of prolidase deficiency in fibroblasts using adenovirus mediated gene transfer
- Source :
- Japanese Journal of Human Genetics. 42:401-408
- Publication Year :
- 1997
- Publisher :
- Springer Science and Business Media LLC, 1997.
-
Abstract
- Prolidase deficiency is an autosomal recessive inherited disease characterized clinically by frequent infections, mental retardation, and various skin lesions. Fundamental treatments for these manifestations have not been established. We performed adenovirus-mediated gene transfer of human prolidase cDNA into fibroblasts from patients with prolidase deficiency. Infection with the adenovirus vector carrying human prolidase cDNA increased prolidase activity in fibroblasts up to approximately 7.5 times of that of normal control fibroblasts. This indicates the feasibility of adenovirus-mediated gene therapy to treat patients with prolidase deficiency in the future.
- Subjects :
- Dipeptidases
DNA, Complementary
Genetic enhancement
Genetic Vectors
Genes, Recessive
Gene transfer
Biology
Skin Diseases
Adenoviridae
Viral vector
Complementary DNA
medicine
Humans
RNA, Messenger
Normal control
Cells, Cultured
Genetics (clinical)
Skin
Prolidase deficiency
Gene Transfer Techniques
Genetic Therapy
Fibroblasts
medicine.disease
Frequent infections
Immunology
Female
Inherited disease
Metabolism, Inborn Errors
Subjects
Details
- ISSN :
- 00215074
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Japanese Journal of Human Genetics
- Accession number :
- edsair.doi.dedup.....0c527226cd73d354fbb77aedf48fdd3e